Drug development is one of the most significant processes in the pharmaceutical industry.
Various computational methods have dramatically reduced the time and cost of drug …

With heart and cardiovascular diseases continually challenging healthcare systems
worldwide, translating basic research on cardiac (patho) physiology into clinical care is …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Key points Induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) capture
patient‐specific genotype–phenotype relationships, as well as cell‐to‐cell variability of …

The global burden caused by cardiovascular disease is substantial, with heart disease
representing the most common cause of death around the world. There remains a need to …

Integration of data across spatial, temporal, and functional scales is a primary focus of
biomedical engineering efforts. The advent of powerful computing platforms, coupled with …

Because of the inherent complexity of coupled nonlinear biological systems, the
development of computational models is necessary for achieving a quantitative …

Understanding the basis for differential responses to drug therapies remains a challenge
despite advances in genetics and genomics. Induced pluripotent stem cells (iPSCs) offer an …

The improvement of preclinical cardiotoxicity testing, discovery of new ion-channel-targeted
drugs, and phenoty** and use of stem cell-derived cardiomyocytes and other biologics all …