Oxidative stress-induced damage to the retinal pigment epithelium (RPE) is considered to
be a key factor in age-related macular degeneration (AMD) pathology. RPE cells are …

Age-related macular degeneration (AMD) is a complex, degenerative and progressive eye
disease that usually does not lead to complete blindness, but can result in severe loss of …

Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and
PARK2/Parkin mutations cause autosomal recessive forms of Parkinson's disease. Upon a …

Phagocytosis and degradation of photoreceptor outer segments (POS) by retinal pigment
epithelium (RPE) is fundamental to vision. Autophagy is also responsible for bulk …

Maintenance of protein homeostasis, also referred to as “Proteostasis”, integrates multiple
pathways that regulate protein synthesis, folding, translocation, and degradation. Failure in …

Cholesterol homeostasis is crucial for cellular and systemic function. The disorder of
cholesterol metabolism not only accelerates the onset of cardiovascular disease (CVD) but …

ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) transporters that is
preferentially localized along the rim region of rod and cone photoreceptor outer segment …

Retinal pigment epithelial (RPE) cell dysfunction plays a central role in various retinal
degenerative diseases, but knowledge is limited regarding the pathways responsible for …

Retinal pigment epithelium (RPE) is a polarized cell layer critical for photoreceptor function
and survival. The unique physiology and relationship to the photoreceptors make the RPE a …

Aims Blue light is an identified risk factor for age-related macular degeneration (AMD). We
investigated oxidative stress markers and mitochondrial changes in A2E-loaded retinal …