Agarose-based biomaterials for tissue engineering

P Zarrintaj, S Manouchehri, Z Ahmadi, MR Saeb… - Carbohydrate …, 2018 - Elsevier
Agarose is a natural polysaccharide polymer having unique characteristics that give reason
to consider it for tissue engineering applications. Special characteristics of agarose such as …

How can machine learning and multiscale modeling benefit ocular drug development?

N Wang, Y Zhang, W Wang, Z Ye, H Chen, G Hu… - Advanced Drug Delivery …, 2023 - Elsevier
The eyes possess sophisticated physiological structures, diverse disease targets, limited
drug delivery space, distinctive barriers, and complicated biomechanical processes …

Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma

B Kong, Y Chen, R Liu, X Liu, C Liu, Z Shao… - Nature …, 2020 - nature.com
Regeneration of corneal stroma has always been a challenge due to its sophisticated
structure and keratocyte-fibroblast transformation. In this study, we fabricate grid poly (ε …

Scaffold: a novel carrier for cell and drug delivery

T Garg, O Singh, S Arora… - Critical Reviews™ in …, 2012 - dl.begellhouse.com
Scaffolds are implants or injects, which are used to deliver cells, drugs, and genes into the
body. Different forms of polymeric scaffolds for cell/drug delivery are available:(1) a typical …

Designing scaffolds for corneal regeneration

M Ahearne, J Fernández‐Pérez… - Advanced Functional …, 2020 - Wiley Online Library
Corneal blindness is one of the most common causes of vision loss worldwide, affecting
millions of people. To treat these patients, researchers have been examining different …

Natural–origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications

PB Malafaya, GA Silva, RL Reis - Advanced drug delivery reviews, 2007 - Elsevier
The present paper intends to overview a wide range of natural–origin polymers with special
focus on proteins and polysaccharides (the systems more inspired on the extracellular …

Fibrin: a versatile scaffold for tissue engineering applications

TAE Ahmed, EV Dare, M Hincke - Tissue Engineering Part B …, 2008 - liebertpub.com
Tissue engineering combines cell and molecular biology with materials and mechanical
engineering to replace damaged or diseased organs and tissues. Fibrin is a critical blood …

A review of three-dimensional in vitro tissue models for drug discovery and transport studies

NT Elliott, FAN Yuan - Journal of pharmaceutical sciences, 2011 - Elsevier
The use of animal models in drug discovery studies presents issues with feasibility and
ethical concerns. To address these limitations, in vitro tissue models have been developed …

Corneal bioprinting utilizing collagen‐based bioinks and primary human keratocytes

DF Duarte Campos, M Rohde, M Ross… - … Research Part A, 2019 - Wiley Online Library
Corneal transplantation is the treatment of choice for patients with advanced corneal
diseases. However, the outcome may be affected by graft rejection, high associated costs …

Cell encapsulation using biopolymer gels for regenerative medicine

NC Hunt, LM Grover - Biotechnology letters, 2010 - Springer
There has been a consistent increase in the mean life expectancy of the population of the
developed world over the past century. Healthy life expectancy, however, has not increased …