Antibiotics with antibiofilm activity–Rifampicin and beyond

L Ferreira, E Pos, DR Nogueira, FP Ferreira… - Frontiers in …, 2024 - frontiersin.org
The management of prosthetic joint infections is a complex and multilayered process that is
additionally complicated by the formation of bacterial biofilm. Foreign material provides the …

[HTML][HTML] High and low dosage of Vancomycin in Polymethylmethacrylate cements: Efficacy and Mechanical properties

JW Kwong, M Abramowicz, KD Kühn, C Foelsch… - Antibiotics, 2024 - mdpi.com
Introduction: Prosthetic joint infections (PJIs) are difficult to treat and represent a significant
burden to the healthcare system. Two-stage revision surgery with placement of an antibiotic …

Effectiveness of clindamycin-based exposure strategies in experimental mature staphylococcal biofilms

SCJ van Dun, M Verheul, B Pijls, H Scheper… - Microbiology …, 2025 - journals.asm.org
Due to increasing antimicrobial resistance and side effects caused by current standard
antimicrobial regimens used for treatment of prosthetic joint infection (PJI), alternative …

[HTML][HTML] Early staphylococcal Periprosthetic joint infection (PJI) treated with debridement, antibiotics, and implant retention (DAIR): inferior outcomes in patients with …

HK Eriksson, S Lazarinis, JD Järhult, NP Hailer - Antibiotics, 2023 - mdpi.com
It is unknown how rifampicin resistance in staphylococci causing a periprosthetic joint
infection (PJI) affects outcomes after debridement, antibiotics, and implant retention (DAIR) …

Never mind the bug: no differences in infection-free survival after periprosthetic joint infections with Staphylococcus aureus, Coagulase-negative Staphylococcus, or …

A Brüggemann, NP Hailer - Frontiers in Microbiology, 2025 - frontiersin.org
Background Periprosthetic joint infection (PJI) is a devastating complication following
arthroplasty of the hip or knee joint and can be challenging to treat, depending on the …

Rifampin-resistant periprosthetic joint infections are associated with worse functional outcome in both acute and chronic infection types

T Baumgärtner, M Bdeir, FJ Dally, S Gravius… - … and Infectious Disease, 2024 - Elsevier
Periprosthetic joint infections (PJI) pose a significant challenge in orthopaedic surgery, often
requiring extensive surgical debridement and prolonged antibiotic treatment to eliminate the …