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Lung microbiome: new insights into the pathogenesis of respiratory diseases
The lungs were long thought to be sterile until technical advances uncovered the presence
of the lung microbial community. The microbiome of healthy lungs is mainly derived from the …
of the lung microbial community. The microbiome of healthy lungs is mainly derived from the …
Immune-checkpoint inhibitors: long-term implications of toxicity
The development of immune-checkpoint inhibitors (ICIs) has heralded a new era in cancer
treatment, enabling the possibility of long-term survival in patients with metastatic disease …
treatment, enabling the possibility of long-term survival in patients with metastatic disease …
Pathogenic mechanisms underlying idiopathic pulmonary fibrosis
The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …
Challenges of sarcoidosis and its management
Sarcoidosis Sarcoidosis is a lung disease of unknown cause characterized by noncaseating
granulomas; the heart and nervous system may also be involved. It is often misdiagnosed; …
granulomas; the heart and nervous system may also be involved. It is often misdiagnosed; …
Targeting STAT3 in cancer immunotherapy
S Zou, Q Tong, B Liu, W Huang, Y Tian, X Fu - Molecular cancer, 2020 - Springer
As a point of convergence for numerous oncogenic signaling pathways, signal transducer
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …
and activator of transcription 3 (STAT3) is central in regulating the anti-tumor immune …
Transforming growth factor–β in tissue fibrosis
TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …
Shared and distinct mechanisms of fibrosis
Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …
[HTML][HTML] Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation
Granulomas are lumps of immune cells that can form in various organs. Most granulomas
appear unstructured, yet they have some resemblance to lymphoid organs. To better …
appear unstructured, yet they have some resemblance to lymphoid organs. To better …
Therapeutically exploiting STAT3 activity in cancer—using tissue repair as a road map
The tightly orchestrated temporal and spatial control of signal transducer and activator of
transcription 3 (STAT3) activity in epithelial, immune and stromal cells is critical for wound …
transcription 3 (STAT3) activity in epithelial, immune and stromal cells is critical for wound …
[HTML][HTML] Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …