Flavone-C-glycosides from Cassia auriculata L. as possible inhibitors of phosphodiesterase-5 (PDE5): in vitro, molecular docking and molecular dynamics studies
A Ganapathy A, VM Hari Priya, K Baby… - Journal of …, 2024 - Taylor & Francis
Abstract Phosphodiesterase-5 (PDE5) is a homodimeric enzyme that specifically targets
cyclic guanosine monophosphate (cGMP), that mediates many downstream effects such as …
cyclic guanosine monophosphate (cGMP), that mediates many downstream effects such as …
Effects of flavonoids on SARS–CoV–2 main protease (6W63): A molecular docking study
T Ertan-bolelli, K Bolelli… - Turkish …, 2023 - dergipark.org.tr
Public health is still under attack by a worldwide pandemic caused by a coronavirus which is
known to cause mainly respiratory and enteric disease in humans. Currently, still limited …
known to cause mainly respiratory and enteric disease in humans. Currently, still limited …
Computational approaches in the development of phosphodiesterase inhibitors
Computational drug design tools have become indispensable in the quest for new drugs.
There is hardly any drug discovery program where computational methods are not …
There is hardly any drug discovery program where computational methods are not …
Structural investigation of vesnarinone at the pore domains of open and open-inactivated states of hERG1 K+ channel
In this study, the dynamics of vesnarinone bounded hERG1 K+ channels are investigated
using in silico approaches such as molecular docking, molecular dynamics (MD) …
using in silico approaches such as molecular docking, molecular dynamics (MD) …
[PDF][PDF] In silico design of hERG non-blocker compounds with retained pharmacological activity using multi-scale molecular modeling applications
G Kayık - 2017 - polen.itu.edu.tr
The subject of this Ph. D. thesis is to investigate the molecular interactions between hERG
blocker compounds and the central inner cavities of hERG K+ ion channels (in its open and …
blocker compounds and the central inner cavities of hERG K+ ion channels (in its open and …
[PDF][PDF] the body in movement: a clinical approach
M Probst, J Diedens - 2017 - lirias.kuleuven.be
Physiotherapy or body oriented therapy is often overlooked as an adjunctive treatment for
patients with eating disorders (ED). However, the integration of physiotherapy is based on …
patients with eating disorders (ED). However, the integration of physiotherapy is based on …
[PDF][PDF] Aktuální možnosti a trendy v léčbě erektilní dysfunkce
MUDO Štanc - urologiepropraxi.cz
Erectile dysfunction (ED) is a very frequent disease. The past decades have witnessed a
dramatic development in its treatment, associated with an increased interest in this issue by …
dramatic development in its treatment, associated with an increased interest in this issue by …