Plant-inspired building blocks for future plastics
The transition from a linear fossil-based economy to a renewable circular economy requires
a new approach to produce building blocks for plastics. This provides opportunities to …
a new approach to produce building blocks for plastics. This provides opportunities to …
[HTML][HTML] Model-assisted CRISPRi/a library screening reveals central carbon metabolic targets for enhanced recombinant protein production in yeast
Production of recombinant proteins is regarded as an important breakthrough in the field of
biomedicine and industrial biotechnology. Due to the complexity of the protein secretory …
biomedicine and industrial biotechnology. Due to the complexity of the protein secretory …
[HTML][HTML] Knock-out of the major regulator Flo8 in Komagataella phaffii results in unique host strain performance for methanol-free recombinant protein production
C Rebnegger, M Flores-Villegas, V Kowarz, S De… - New …, 2024 - Elsevier
Flo8 is a main transcriptional regulator of flocculation and pseudohyphal growth in yeast.
Disruption of FLO8 in the popular recombinant protein production host Komagataella phaffii …
Disruption of FLO8 in the popular recombinant protein production host Komagataella phaffii …
[HTML][HTML] Synthetic transcription factors establish the function of nine amino acid transactivation domains of Komagataella phaffii Mxr1
P Priya, VB Shivashankar, PN Rangarajan - Journal of Biological Chemistry, 2025 - Elsevier
The zinc finger transcription factor Mxr1 (methanol expression regulator 1) of the
methylotrophic yeast Komagataella phaffii (formerly Pichia pastoris) harbors a DNA-binding …
methylotrophic yeast Komagataella phaffii (formerly Pichia pastoris) harbors a DNA-binding …
Precision Fermentation as an Alternative to Animal Protein, a Review
The global food production system faces several challenges, including significant
environmental impacts due to traditional agricultural practices. The rising demands of …
environmental impacts due to traditional agricultural practices. The rising demands of …
Characterization of the exopolysaccharides produced by the industrial yeast Komagataella phaffii
A Fischer, V Castagna, S Omer… - Journal of Industrial …, 2024 - academic.oup.com
The yeast Komagataella phaffii has become a popular host strain among biotechnology start-
up companies for producing recombinant proteins for food and adult nutrition applications …
up companies for producing recombinant proteins for food and adult nutrition applications …
Yeast-based production platform for potent and stable heavy chain-only antibodies
C Lonigro, H Eeckhaut, RA Symakani, K Roose… - bioRxiv, 2024 - biorxiv.org
Monoclonal antibodies are the leading drug of the biopharmaceutical market because of
their high specificity and tolerability, but the current CHO-based manufacturing platform …
their high specificity and tolerability, but the current CHO-based manufacturing platform …
Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii
Y Yang - 2024 - dspace.mit.edu
Biopharmaceutical products constitute a significant portion of the global bioeconomy.
Compared to traditional synthetic small-molecule drugs, recombinant therapeutic proteins …
Compared to traditional synthetic small-molecule drugs, recombinant therapeutic proteins …