[HTML][HTML] Cognitive impairment in people with epilepsy

A Novak, K Vizjak, M Rakusa - Journal of Clinical Medicine, 2022 - mdpi.com
People with epilepsy frequently have cognitive impairment. The majority of cognitive
problems is influenced by a variety of interlinked factors, including the early onset of …

Epilepsy in older people

A Sen, N Jette, M Husain, JW Sander - The Lancet, 2020 - thelancet.com
Globally, as populations age there will be challenges and opportunities to deliver optimal
health care to senior citizens. Epilepsy, a condition characterised by spontaneous recurrent …

Cognition and dementia in older patients with epilepsy

A Sen, V Capelli, M Husain - Brain, 2018 - academic.oup.com
With advances in healthcare and an ageing population, the number of older adults with
epilepsy is set to rise substantially across the world. In developed countries the highest …

[HTML][HTML] Epileptic-network-based prediction and control of seizures in humans

K Lehnertz, T Bröhl, R von Wrede - Neurobiology of disease, 2023 - Elsevier
Epilepsy is now conceptualized as a network disease. The epileptic brain network
comprises structurally and functionally connected cortical and subcortical brain regions …

[HTML][HTML] Microglial depletion aggravates the severity of acute and chronic seizures in mice

W Wu, Y Li, Y Wei, DB Bosco, M **e, MG Zhao… - Brain, behavior, and …, 2020 - Elsevier
Microglia are the resident immune cells of the center nervous system and participate in
various neurological diseases. Here we determined the function of microglia in …

Focal epilepsy disrupts spindle structure and function

K Schiller, T Avigdor, C Abdallah, V Sziklas, J Crane… - Scientific reports, 2022 - nature.com
Sleep spindles are the hallmark of N2 sleep and are attributed a key role in cognition. Little
is known about the impact of epilepsy on sleep oscillations underlying sleep-related …

The role of the adenosine system in epilepsy and its comorbidities

JA Baltos, PM Casillas‐Espinosa… - British Journal of …, 2024 - Wiley Online Library
Epilepsy is one of the most serious and common chronic neurological conditions,
characterised by recurrent hypersynchronous electrical activity in the brain that lead to …

Sex differences in the epilepsies and associated comorbidities: implications for use and development of pharmacotherapies

CA Christian, DS Reddy, J Maguire… - Pharmacological Reviews, 2020 - Elsevier
The epilepsies are common neurologic disorders characterized by spontaneous recurrent
seizures. Boys, girls, men, and women of all ages are affected by epilepsy and, in many …

Epilepsy and Alzheimer's Disease: Potential mechanisms for an association

FS Giorgi, LF Saccaro, CL Busceti, F Biagioni… - Brain Research …, 2020 - Elsevier
Alzheimer's Disease (AD) and epilepsy are common neurological diseases. The prevalence
of epilepsy in AD patients is higher than in healthy subjects, but identifying the reasons for …

Epilepsy and its neurobehavioral comorbidities: Insights gained from animal models

W Löscher, CE Stafstrom - Epilepsia, 2023 - Wiley Online Library
It is well established that epilepsy is associated with numerous neurobehavioral
comorbidities, with a bidirectional relationship; people with epilepsy have an increased …