Outcome measures in clinical trials for multiple sclerosis

CEP van Munster, BMJ Uitdehaag - CNS drugs, 2017 - Springer
Due to the heterogeneous nature of the disease, it is a challenge to capture disease activity
of multiple sclerosis (MS) in a reliable and valid way. Therefore, it can be difficult to assess …

Past, present and future role of retinal imaging in neurodegenerative disease

AH Kashani, S Asanad, JW Chan, MB Singer… - Progress in retinal and …, 2021 - Elsevier
Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts
of information about the structure, function and molecular composition of retinal tissue in …

Optical coherence tomography reflects brain atrophy in multiple sclerosis: a four‐year study

S Saidha, O Al‐Louzi, JN Ratchford… - Annals of …, 2015 - Wiley Online Library
Objective The aim of this work was to determine whether atrophy of specific retinal layers
and brain substructures are associated over time, in order to further validate the utility of …

Optical coherence tomography in multiple sclerosis: a 3‐year prospective multicenter study

F Paul, PA Calabresi, F Barkhof… - Annals of clinical …, 2021 - Wiley Online Library
Objective To evaluate changes over 3 years in the thickness of inner retinal layers including
the peripapillary retinal nerve fiber layer (pRNFL), and combined macular ganglion cell and …

Optical coherence tomography in multiple sclerosis

J Britze, JL Frederiksen - Eye, 2018 - nature.com
To summarize recent findings regarding the utility of optical coherence tomography in
multiple sclerosis. We searched PubMed for relevant articles using the keywords 'optical …

Vision and vision-related outcome measures in multiple sclerosis

LJ Balcer, DH Miller, SC Reingold, JA Cohen - Brain, 2015 - academic.oup.com
Visual impairment is a key manifestation of multiple sclerosis. Acute optic neuritis is a
common, often presenting manifestation, but visual deficits and structural loss of retinal …

Trans‐synaptic axonal degeneration in the visual pathway in multiple sclerosis

I Gabilondo, EH Martínez‐Lapiscina… - Annals of …, 2014 - Wiley Online Library
Objective To evaluate the association between the damage to the anterior and posterior
visual pathway as evidence of the presence of retrograde and anterograde trans‐synaptic …

Microcystic macular oedema, thickness of the inner nuclear layer of the retina, and disease characteristics in multiple sclerosis: a retrospective study

S Saidha, ES Sotirchos, MA Ibrahim… - The Lancet …, 2012 - thelancet.com
Background Microcystic macular oedema (MMO) of the retinal inner nuclear layer (INL) has
been identified in patients with multiple sclerosis (MS) by use of optical coherence …

[HTML][HTML] Schizophrenia and the eye

SM Silverstein, R Rosen - Schizophrenia Research: Cognition, 2015 - Elsevier
Although visual processing impairments are common in schizophrenia, it is not clear to what
extent these originate in the eye vs. the brain. This review highlights potential contributions …

Validity of low-contrast letter acuity as a visual performance outcome measure for multiple sclerosis

LJ Balcer, J Raynowska, R Nolan… - Multiple Sclerosis …, 2017 - journals.sagepub.com
Low-contrast letter acuity (LCLA) has emerged as the leading outcome measure to assess
visual disability in multiple sclerosis (MS) research. As visual dysfunction is one of the most …