The secretory pathway is responsible for the synthesis, folding, and delivery of a diverse
array of cellular proteins. Secretory protein synthesis begins in the endoplasmic reticulum …

The trafficking of proteins within eukaryotic cells is achieved by the capture of cargo and
targeting molecules into vesicles that bud from a donor membrane and deliver their contents …

Dilysine motifs in cytoplasmic domains of transmembrane proteins are signals for their
continuous retrieval from the Golgi back to the endoplasmic reticulum (El?). We describe a …

Transport of membranes and proteins in eukaryotic cells is mediated by vesicular carriers.
Here we review the biogenesis and functions of COPI vesicles, carriers that operate in the …

Exocytic transport from the endoplasmic reticulum (ER) to the Golgi complex has been
visualized in living cells using a chimera of the temperature-sensitive glycoprotein of …

Electron microscope immunocytochemistry reveals that both anterograde-directed
(proinsulin and VSV G protein) and retrograde-directed (the KDEL receptor) cargo are …

COPI and COPII are vesicle coat complexes whose assembly is regulated by the ARF1 and
Sarl GTPases, respectively. We show that COPI and COPII coat complexes are recruited …

Brefeldin A (BFA) causes a block in the secretory system of eukaryotic cells by inhibiting
vesicle formation at the Golgi apparatus. Although this toxin has been used in many studies …

Nowadays, it is imperative to identify the combination of profitable products (nodes) within
large product networks. Data exploration for such broad-spectrum product networks require …

We find that the peripheral ER in Saccharomyces cerevisiae forms a dynamic network of
interconnecting membrane tubules throughout the cell cycle, similar to the ER in higher …