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The neurobiology of depression and antidepressant action
We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …
Serotonin, amygdala and fear: assembling the puzzle
The fear circuitry orchestrates defense mechanisms in response to environmental threats.
This circuitry is evolutionarily crucial for survival, but its dysregulation is thought to play a …
This circuitry is evolutionarily crucial for survival, but its dysregulation is thought to play a …
The subcortical and neurochemical organization of the ventral and dorsal attention networks
Attention is a core cognitive function that filters and selects behaviourally relevant
information in the environment. The cortical map** of attentional systems identified two …
information in the environment. The cortical map** of attentional systems identified two …
[HTML][HTML] Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers
Objectives The present study explored the effects of two prebiotics on the secretion of the
stress hormone, cortisol and emotional processing in healthy volunteers. Methods Forty-five …
stress hormone, cortisol and emotional processing in healthy volunteers. Methods Forty-five …
Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action
BackgroundThe neuropharmacological actions of antidepressants are well characterised
but our understanding of how these changes translate into improved mood are still …
but our understanding of how these changes translate into improved mood are still …
Serotoninergic regulation of emotional and behavioural control processes
5-Hydroxytryptamine (5-HT, serotonin) has long been implicated in a wide variety of
emotional, cognitive and behavioural control processes. However, its precise contribution is …
emotional, cognitive and behavioural control processes. However, its precise contribution is …
Affective cognition and its disruption in mood disorders
In this review, we consider affective cognition, responses to emotional stimuli occurring in
the context of cognitive evaluation. In particular, we discuss emotion categorization, biasing …
the context of cognitive evaluation. In particular, we discuss emotion categorization, biasing …
Serotonin modulates sensitivity to reward and negative feedback in a probabilistic reversal learning task in rats
Depressed patients show cognitive deficits that may depend on an abnormal reaction to
positive and negative feedback. The precise neurochemical mechanisms responsible for …
positive and negative feedback. The precise neurochemical mechanisms responsible for …
Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment
Depression is a leading cause of disability worldwide and improving its treatment is a core
research priority for future programmes. A change in the view of psychological and …
research priority for future programmes. A change in the view of psychological and …
Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man
Glucocorticoids (GCs) are secreted in an ultradian, pulsatile pattern that emerges from
delays in the feedforward-feedback interaction between the anterior pituitary and adrenal …
delays in the feedforward-feedback interaction between the anterior pituitary and adrenal …