Nicotinic acetylcholine receptors (nAChRs) are pentameric neurotransmitter receptors. They
are members of the Cys-loop family of ligand-gated ion channels which also include …

The clinical development of selective alpha-7 nicotinic acetylcholine receptor (α7 nAChR)
agonists has hitherto been focused on disorders characterized by cognitive deficits (eg …

As a reversible posttranslational modification, protein palmitoylation has the potential to
regulate the trafficking and function of a variety of proteins. However, the extent, function …

Nicotine exerts its behavioral and additive actions through a family of brain nicotinic
acetylcholine receptors (nAChRs). Enhancing α7-type nAChR signaling improves symptoms …

Accumulating data suggest that α7 nicotinic acetylcholine receptors (α7nAChRs) are an
important therapeutic target for the treatment of Alzheimer's disease (AD) and schizophrenia …

Mutations in ric‐3 (r esistant to i nhibitors of c holinesterase) suppress the neuronal
degenerations caused by a gain of function mutation in the Caenorhabditis elegans DEG‐3 …

Octopamine is a neuromodulator that mediates diverse physiological processes in
invertebrates. In some insects, such as honeybees and fruit flies, octopamine has been …

Heterologous expression of the cystic fibrosis transmembrane conductance regulator
(CFTR) provided evidence that the major cystic fibrosis (CF) mutation ΔF508 leads to …

Chronic exposure to nicotine elicits upregulation of high-affinity nicotinic receptors in the
smoker's brain. To address the molecular mechanism of upregulation, we transfected …

Methyllycaconitine (MLA), a norditerpenoid alkaloid isolated from Delphinium seeds, is one
of the most potent non-proteinacious ligands that is selective for αbungarotoxin-sensitive …