[HTML][HTML] Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis
J Wang, K Hu, X Cai, B Yang, Q He, J Wang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial pneumonia
with unknown causes. The incidence rate increases year by year and the prognosis is poor …
with unknown causes. The incidence rate increases year by year and the prognosis is poor …
Pharmacology of adenosine receptors: the state of the art
Adenosine is a ubiquitous endogenous autacoid whose effects are triggered through the
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …
enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Due to the rapid …
Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract
The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …
Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis
PA Reyfman, JM Walter, N Joshi… - American journal of …, 2019 - atsjournals.org
Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal …
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal …
SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis
Background Severe acute respiratory syndrome (SARS)-CoV-2-induced coronavirus
disease-2019 (COVID-19) is a pandemic disease that affects> 2.8 million people worldwide …
disease-2019 (COVID-19) is a pandemic disease that affects> 2.8 million people worldwide …
Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis
G Coulis, D Jaime, C Guerrero-Juarez… - Science …, 2023 - science.org
Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …
Lung myofibroblasts promote macrophage profibrotic activity through lactate-induced histone lactylation
Augmented glycolysis due to metabolic reprogramming in lung myofibroblasts is critical to
their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into …
their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into …
Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease
Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …
[HTML][HTML] SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis
Summary COVID-19-induced" acute respiratory distress syndrome"(ARDS) is associated
with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury …
with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury …
[CITAZIONE][C] Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis
C Morse, T Tabib, J Sembrat… - European …, 2019 - Eur Respiratory Soc