Plant cell factories in the post-genomic era: new ways to produce designer secondary metabolites

KM Oksman-Caldentey, D Inzé - Trends in plant science, 2004 - cell.com
Plants synthesize an extensive array of secondary metabolites, often with highly complex
structures. Currently, most pharmaceutically important secondary metabolites are isolated …

Tilting plant metabolism for improved metabolite biosynthesis and enhanced human benefit

B Ncube, J Van Staden - Molecules, 2015 - mdpi.com
The immense chemical diversity of plant-derived secondary metabolites coupled with their
vast array of biological functions has seen this group of compounds attract considerable …

Nicotine's defensive function in nature

A Steppuhn, K Gase, B Krock, R Halitschke… - PLoS …, 2004 - journals.plos.org
Plants produce metabolites that directly decrease herbivore performance, and as a
consequence, herbivores are selected for resistance to these metabolites. To determine …

Molecular genetics of alkaloid biosynthesis in Nicotiana tabacum

RE Dewey, J **e - Phytochemistry, 2013 - Elsevier
Alkaloids represent an extensive group of nitrogen-containing secondary metabolites that
are widely distributed throughout the plant kingdom. The pyridine alkaloids of tobacco …

Genetic regulation and manipulation of nicotine biosynthesis in tobacco: strategies to eliminate addictive alkaloids

T Shoji, T Hashimoto, K Saito - Journal of Experimental Botany, 2024 - academic.oup.com
Tobacco (Nicotiana tabacum L.) is a widely cultivated crop of the genus Nicotiana. Due to
the highly addictive nature of tobacco products, tobacco smoking remains the leading cause …

APETALA2/ETHYLENE RESPONSE FACTOR and basic helix–loop–helix tobacco transcription factors cooperatively mediate jasmonate‐elicited nicotine biosynthesis

K De Boer, S Tilleman, L Pauwels… - The Plant …, 2011 - Wiley Online Library
Transcription factors of the plant‐specific apetala2/ethylene response factor (AP2/ERF)
family control plant secondary metabolism, often as part of signalling cascades induced by …

[BOEK][B] Plant cell and tissue culture-A tool in Biotechnology

KH Neumann, A Kumar, J Imani - 2009 - Springer
This book is intended to provide a general introduction to this exciting field of plant cell and
tissue culture as tool in biotechnology, without overly dwelling on detailed descriptions of all …

Resistance management in a native plant: nicotine prevents herbivores from compensating for plant protease inhibitors

A Steppuhn, IT Baldwin - Ecology Letters, 2007 - Wiley Online Library
Plants deploy chemical defenses in complex mixtures, which are thought to be adaptive, but
experimental tests have used artificial diets rather than plants. Herbivore attack on Nicotiana …

An improved Nicotiana benthamiana bioproduction chassis provides novel insights into nicotine biosynthesis

K Vollheyde, QM Dudley, T Yang, MT Oz… - New …, 2023 - Wiley Online Library
The model plant Nicotiana benthamiana is an increasingly attractive organism for the
production of high‐value, biologically active molecules. However, N. benthamiana …

Improvement of phytochemical production by plant cells and organ culture and by genetic engineering

E Nielsen, MEE Temporiti, R Cella - Plant cell reports, 2019 - Springer
Plants display an amazing ability to synthesize a vast array of secondary metabolites that
are an inexhaustible source of phytochemicals, bioactive molecules some of which impact …