[HTML][HTML] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

LM Butler, Y Perone, J Dehairs, LE Lupien… - Advanced drug delivery …, 2020 - Elsevier
With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

[HTML][HTML] Fatty acid synthase: an emerging target in cancer

CW Fhu, A Ali - Molecules, 2020 - mdpi.com
In recent years, lipid metabolism has garnered significant attention as it provides the
necessary building blocks required to sustain tumor growth and serves as an alternative fuel …

The role of PPAR-δ in metabolism, inflammation, and cancer: many characters of a critical transcription factor

Y Liu, JK Colby, X Zuo, J Jaoude, D Wei… - International journal of …, 2018 - mdpi.com
Peroxisome proliferator-activated receptor-delta (PPAR-δ), one of three members of the
PPAR group in the nuclear receptor superfamily, is a ligand-activated transcription factor …

The biology of tardigrade disordered proteins in extreme stress tolerance

C Hesgrove, TC Boothby - Cell Communication and Signaling, 2020 - Springer
Disordered proteins have long been known to help mediate tolerance to different abiotic
stresses including freezing, osmotic stress, high temperatures, and desiccation in a diverse …

Emerging hallmarks of metabolic reprogramming in prostate cancer

F Lasorsa, NA di Meo, M Rutigliano, M Ferro… - International Journal of …, 2023 - mdpi.com
Prostate cancer (PCa) is the most common male malignancy and the fifth leading cause of
cancer death in men worldwide. Prostate cancer cells are characterized by a hybrid …

FABP4 in obesity-associated carcinogenesis: Novel insights into mechanisms and therapeutic implications

S Liu, D Wu, Z Fan, J Yang, Y Li, Y Meng… - Frontiers in Molecular …, 2022 - frontiersin.org
The increasing prevalence of obesity worldwide is associated with an increased risk of
various diseases, including multiple metabolic diseases, cardiovascular diseases, and …

Fatty acid metabolism-related enzymes in colorectal cancer metastasis: from biological function to molecular mechanism

B Li, J Mi, Q Yuan - Cell Death Discovery, 2024 - nature.com
Colorectal cancer (CRC) is a highly aggressive and life-threatening malignancy that
metastasizes in~ 50% of patients, posing significant challenges to patient survival and …

Fatty acids in cancer chemoresistance

J Qin, L Ye, X Wen, X Zhang, Y Di, Z Chen, Z Wang - Cancer Letters, 2023 - Elsevier
Despite the remarkable clinical success of immunotherapy and molecular targeted therapy
in patients with advanced tumors, chemotherapy remains the most commonly used …

Clinical significance of carnitine in the treatment of cancer: from traffic to the regulation

R Farahzadi, MS Hejazi, O Molavi… - Oxidative Medicine …, 2023 - Wiley Online Library
Metabolic reprogramming is a common hallmark of cancer cells. Cancer cells exhibit
metabolic flexibility to maintain high proliferation and survival rates. In other words …

[HTML][HTML] FABP5 as a novel molecular target in prostate cancer

SE O'Sullivan, M Kaczocha - Drug Discovery Today, 2020 - Elsevier
Highlights•Fatty acid binding protein 5 (FABP5) is upregulated in many cancers, particularly
prostate cancer (PC).•FABP5 facilitates the delivery of fatty acids to peroxisome proliferator …