NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …

Nicotinamide riboside is a precursor to the important cofactor nicotinamide adenine
dinucleotide and has elicited metabolic benefits in multiple preclinical studies. In 2016, the …

Mitochondria require nicotinamide adenine dinucleotide (NAD+) to carry out the
fundamental processes that fuel respiration and mediate cellular energy transduction …

Key points This is the first long‐term human clinical trial to report on effects of nicotinamide
riboside (NR) on skeletal muscle mitochondrial function, content and morphology. NR …

Molecular clocks in the periphery coordinate tissue-specific daily biorhythms by integrating
input from the hypothalamic master clock and intracellular metabolic signals. One such key …

Aging decreases skeletal muscle mass and strength, but aerobic and resistance exercise
training maintains skeletal muscle function. NAD+ is a coenzyme for ATP production and a …

BACKGROUND During aging, there is a functional decline in the pool of muscle stem cells
(MuSCs) that influences the functional and regenerative capacity of skeletal muscle …

Abstract Background Nicotinamide phosphoribosyltransferase (Nampt), a key enzyme in
NAD salvage pathway is decreased in metabolic diseases, and its precise role in skeletal …

Objective NAD+ is a co-factor and substrate for enzymes maintaining energy homeostasis.
Nicotinamide phosphoribosyltransferase (NAMPT) controls NAD+ synthesis, and in skeletal …

Maternal obesity is associated with multiple adverse reproductive outcomes, whereas the
underlying molecular mechanisms are still not fully understood. Here, we found the reduced …