Astrocytes derived from neural progenitor cells are susceptible to Zika virus infection

EI Rubio-Hernández, M Comas-García… - PLoS …, 2023 - journals.plos.org
Zika virus (ZIKV) was first isolated in 1947. From its isolation until 2007, symptoms of ZIKV-
caused disease were limited (eg, fever, hives, and headache); however, during the epidemic …

Internalization and toxicity of polystyrene nanoplastics on inmortalized human neural stem cells

MC González-Caballero, M de Alba González… - Chemosphere, 2024 - Elsevier
Global plastic production has increased exponentially in recent decades, and a significant
part of it persists in the environment, where it degrades into microplastics and nanoplastics …

Fetal brain damage in human fetuses with congenital cytomegalovirus infection: histological features and viral tropism

G Piccirilli, L Gabrielli, MP Bonasoni… - Cellular and Molecular …, 2023 - Springer
Human cytomegalovirus (HCMV) causes congenital neurological lifelong disabilities. To
date, the neuropathogenesis of brain injury related to congenital HCMV (cCMV) infection is …

Human cytomegalovirus disruption of calcium signaling in neural progenitor cells and organoids

SL Sison, BS O'Brien, AJ Johnson… - Journal of …, 2019 - Am Soc Microbiol
The herpesvirus human cytomegalovirus (HCMV) is a leading cause of congenital birth
defects. Infection can result in infants born with a variety of symptoms, including …

Machine Learning and Artificial Intelligence for the Prediction of Host–Pathogen Interactions: A Viral Case

A Yakimovich - Infection and Drug Resistance, 2021 - Taylor & Francis
The research of interactions between the pathogens and their hosts is key for understanding
the biology of infection. Commencing on the level of individual molecules, these interactions …

[HTML][HTML] Downregulation of neurodevelopmental gene expression in iPSC-derived cerebral organoids upon infection by human cytomegalovirus

BS O'Brien, RL Mokry, ML Schumacher, K Pulakanti… - Iscience, 2022 - cell.com
Human cytomegalovirus (HCMV) is a betaherpesvirus that can cause severe birth defects
including vision and hearing loss, microcephaly, and seizures. Currently, no approved …

Nitric oxide attenuates human cytomegalovirus infection yet disrupts neural cell differentiation and tissue organization

RL Mokry, BS O'Brien, JW Adelman, S Rosas… - Journal of …, 2022 - Am Soc Microbiol
Human cytomegalovirus (HCMV) is a prevalent betaherpesvirus that is asymptomatic in
healthy individuals but can cause serious disease in immunocompromised patients. HCMV …

Blood-based T cell receptor anti-viral CDR3s are associated with worse overall survival for neuroblastoma

DB Kacsoh, MJ Diaz, EC Gozlan, A Sahoo… - Journal of Cancer …, 2023 - Springer
With the advent of large collections of adaptive immune receptor recombination reads
representing cancer, there is the opportunity to further investigate the adaptive immune …

The antiviral cytokine interferon‐gamma restricts neural stem/progenitor cell proliferation through activation of STAT1 and modulation of retinoblastoma protein …

A Kulkarni, TJ Scully… - Journal of neuroscience …, 2017 - Wiley Online Library
Neural stem/progenitor cells (NPSCs) express receptors for many inflammatory cytokines,
with varying effects on differentiation and proliferation depending on the stage of …

Toxoplasma gondii inhibits differentiation of C17. 2 neural stem cells through Wnt/β-catenin signaling pathway

X Gan, X Zhang, Z Cheng, L Chen, X Ding, J Du… - Biochemical and …, 2016 - Elsevier
Toxoplasma gondii is a major cause of congenital brain disease. T. gondii infection in the
develo** fetus frequently results in major neural developmental damage; however, the …