Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

Colorectal cancer (CRC) is among the most common malignancies with limited treatments
other than surgery. The tumor microenvironment (TME) profiling enables the discovery of …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

The urinary bladder collects urine from the kidneys and stores it until the appropriate
moment for voiding. The trigone and ureterovesical junctions are key to bladder function, by …

Cyclophosphamide may cause hemorrhagic cystitis and eventually bladder urothelial
cancer. Genetic determinants for poor outcomes are unknown. We assessed actions of …

In mammalian ureters, the lamina propria presents as a prominent layer of connective tissue
underneath the urothelium. Despite its important structural and signaling functions, little is …

Urethral hypoplasia, including failure of urethral tube closure, is one of the common
phenotypes observed in hereditary human disorders, the mechanism of which remains …

The mammalian kidney and lower urinary tract maintains and regulates water balance, acid–
base homeostasis, electrolyte equilibrium, and waste excretion. The performance of these …

The coordinated development of the mesenchymal and epithelial progenitors of the murine
ureter depends on a complex interplay of diverse signaling activities. We have recently …

The extracellular matrix of the bladder consists mostly of type I and III collagen, which are
required during loading. During bladder injury, there is an accumulation of collagen that …