Rejection of xenografts is associated with vascular‐based inflammation, thrombocytopenia
and the consumption of coagulation factors that may evolve into disseminated intravascular …

Recent studies suggest that the generation of thrombin and other clotting factors plays a
major role in cellular regulation and probably a variety of disease processes. Many of these …

Extravascular coagulation leading to fibrin deposition accompanies many immune and
inflammatory responses. Although recognized by pathologists for decades, and probably …

Ribavirin, a synthetic guanosine analogue, possesses a broad spectrum of activity against
DNA and RNA viruses. It has been previously shown to attenuate the course of fulminant …

Severe acute respiratory syndrome (SARS) is a life-threatening infectious disease which has
been difficult to study and treat because of the lack of a readily available animal model …

Fibrin deposition and thrombosis within the microvasculature is now appreciated to play a
pivotal role in the hepatocellular injury observed in experimental and human viral hepatitis …

In the present studies, we report the cloning and structural characterization of the HFGL2
gene and its functional role in human fulminant hepatitis. The HFGL2 gene is approximately …

Fibrinogen-like protein 2 (Fgl2), a member of the fibrinogen family, can be expressed as a
membrane-associated protein with coagulation activity or in a secreted form possessing …

Fibrinogen (Fg) and its derivatives play a considerable role in many diseases. For example,
increased levels of Fg have been found in many inflammatory diseases, such as Alzheimer's …

We have recently cloned the human homologue of the murine pT49 cDNA (hpT49h), a
transcript encoding a protein homologous to the β-and γ-chains of fibrinogen. Here, we …