Butyrate producers,“The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics

V Singh, GD Lee, HW Son, H Koh, ES Kim… - Frontiers in …, 2023 - frontiersin.org
Gut-microbial butyrate is a short-chain fatty acid (SCFA) of significant physiological
importance than the other major SCFAs (acetate and propionate). Most butyrate producers …

Gut liver brain axis in diseases: the implications for therapeutic interventions

M Yan, S Man, B Sun, L Ma, L Guo, L Huang… - Signal transduction and …, 2023 - nature.com
Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough …

Role of the gut microbiota and its metabolites in tumorigenesis or development of colorectal cancer

R Qu, Y Zhang, Y Ma, X Zhou, L Sun, C Jiang… - Advanced …, 2023 - Wiley Online Library
Colorectal cancer (CRC) is the most common cancer of the digestive system with high
mortality and morbidity rates. Gut microbiota is found in the intestines, especially the …

Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease

B Jia, Y Zou, X Han, JW Bae, CO Jeon - Trends in microbiology, 2023 - cell.com
Cardiovascular disease (CVD) is a health problem worldwide, and elevated cholesterol
levels are a key risk factor for the disease. Dysbiotic gut microbiota has been shown to be …

Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis

Z Lyu, Y Hu, Y Guo, D Liu - Bone research, 2023 - nature.com
The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being
of the host. Recent studies have demonstrated that the GM may significantly influence bone …

An engineered butyrate-derived polymer nanoplatform as a mucosa-healing enhancer potentiates the therapeutic effect of magnolol in inflammatory bowel disease

X Fan, Z Zhang, W Gao, Q Pan, K Luo, B He, Y Pu - ACS nano, 2023 - ACS Publications
Colonic epithelial damage and dysregulated immune response are crucial factors in the
progression and exacerbation of inflammatory bowel disease (IBD). Nanoenabled targeted …

Clostridium butyricum and its derived extracellular vesicles modulate gut homeostasis and ameliorate acute experimental colitis

L Ma, Q Shen, W Lyu, L Lv, W Wang, M Yu… - Microbiology …, 2022 - journals.asm.org
Microbiological treatments are expected to have a role in the future management of
inflammatory bowel disease (IBD). Clostridium butyricum (C. butyricum) is a probiotic …

[HTML][HTML] Crosstalk between the gut microbiome and colonic motility in chronic constipation: potential mechanisms and microbiota modulation

R Pan, L Wang, X Xu, Y Chen, H Wang, G Wang… - Nutrients, 2022 - mdpi.com
Chronic constipation (CC) is a highly prevalent and burdensome gastrointestinal disorder.
Accumulating evidence highlights the link between imbalances in the gut microbiome and …

Metabolite profiling of human‐originated Lachnospiraceae at the strain level

R Abdugheni, WZ Wang, YJ Wang, MX Du, FL Liu… - Imeta, 2022 - Wiley Online Library
The human gastrointestinal (GI) tract harbors diverse microbes, and the family
Lachnospiraceae is one of the most abundant and widely occurring bacterial groups in the …

The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management

A Nabavi-Rad, A Sadeghi, H Asadzadeh Aghdaei… - Gut …, 2022 - Taylor & Francis
As Helicobacter pylori management has become more challenging and less efficient over
the last decade, the interest in innovative interventions is growing by the day. Probiotic co …