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Genetically modified mesenchymal stromal/stem cells: application in critical illness
AK Varkouhi, APT Monteiro, JN Tsoporis… - Stem Cell Reviews and …, 2020 - Springer
Critical illnesses including sepsis, acute respiratory distress syndromes, ischemic
cardiovascular disorders and acute organ injuries are associated with high mortality …
cardiovascular disorders and acute organ injuries are associated with high mortality …
Use of genetically modified mesenchymal stem cells to treat neurodegenerative diseases
The transplantation of mesenchymal stem cells (MSCs) for treating neurodegenerative
disorders has received growing attention recently because these cells are readily available …
disorders has received growing attention recently because these cells are readily available …
Non-viral gene delivery to human mesenchymal stem cells: a practical guide towards cell engineering
N Carballo-Pedrares, F Ponti, J Lopez-Seijas… - Journal of Biological …, 2023 - Springer
In recent decades, human mesenchymal stem cells (hMSCs) have gained momentum in the
field of cell therapy for treating cartilage and bone injuries. Despite the tri-lineage …
field of cell therapy for treating cartilage and bone injuries. Despite the tri-lineage …
Efficient nonviral transfection of human bone marrow mesenchymal stromal cells shown using placental growth factor overexpression
WY Cheung, O Hovey, JM Gobin… - Stem cells …, 2018 - Wiley Online Library
Background. Human mesenchymal stromal/stem cells (hMSCs) hold great therapeutic
potential due to their immunomodulatory and tissue regenerative properties. Enhancement …
potential due to their immunomodulatory and tissue regenerative properties. Enhancement …
Engineering of Human Mesenchymal Stem/Stromal Cells with Vascular Endothelial Growth Factor–Encoding Minicircles for Angiogenic Ex Vivo Gene Therapy
J Serra, CPA Alves, L Brito, GA Monteiro… - Human Gene …, 2019 - liebertpub.com
Peripheral artery disease (PAD) is a debilitating and prevalent condition characterized by
blockage of the arteries, leading to limb amputation in more severe cases. Mesenchymal …
blockage of the arteries, leading to limb amputation in more severe cases. Mesenchymal …
Effective Gene Delivery into Human Stem Cells with a Cell‐Targeting Peptide‐Modified Bioreducible Polymer
Stem cells are poorly permissive to non‐viral gene transfection reagents. In this study, we
explored the possibility of improving gene delivery into human embryonic (hESC) and …
explored the possibility of improving gene delivery into human embryonic (hESC) and …
Gene delivery in tissue engineering and regenerative medicine
YL Fang, XG Chen, G WT - Journal of Biomedical Materials …, 2015 - Wiley Online Library
As a promising strategy to aid or replace tissue/organ transplantation, gene delivery has
been used for regenerative medicine applications to create or restore normal function at the …
been used for regenerative medicine applications to create or restore normal function at the …
Possibilities and efficiency of MSC co-transfection for gene therapy
S Christoffers, L Seiler, E Wiebe, C Blume - Stem Cell Research & Therapy, 2024 - Springer
Mesenchymal stem/stromal cells (MSCs) are not only capable of self-renewal, trans-
differentiation, homing to damaged tissue sites and immunomodulation by secretion of …
differentiation, homing to damaged tissue sites and immunomodulation by secretion of …
Efficient cytosolic delivery mediated by polymersomes facilely prepared from a degradable, amphiphilic, and amphoteric copolymer
Z Huang, W Teng, L Liu, L Wang, Q Wang… - …, 2013 - iopscience.iop.org
To solve problems in polymersome preparation caused by liposolubility of copolymers and
to improve the cytosolic delivery efficiency of polymersomes to drugs, a lipopolysaccharide …
to improve the cytosolic delivery efficiency of polymersomes to drugs, a lipopolysaccharide …
Transfection of CXCR-4 using microbubble-mediated ultrasound irradiation and liposomes improves the migratory ability of bone marrow stromal cells
G Wang, Z Zhuo, Q Zhang, Y Xu, S Wu, L Li… - Current Gene …, 2015 - ingentaconnect.com
Bone marrow stromal cells (BMSCs) have proven useful for the treatment of various human
diseases and injuries. However, their reparative capacity is limited by their poor migration …
diseases and injuries. However, their reparative capacity is limited by their poor migration …