Genetically modified mesenchymal stromal/stem cells: application in critical illness

AK Varkouhi, APT Monteiro, JN Tsoporis… - Stem Cell Reviews and …, 2020 - Springer
Critical illnesses including sepsis, acute respiratory distress syndromes, ischemic
cardiovascular disorders and acute organ injuries are associated with high mortality …

Use of genetically modified mesenchymal stem cells to treat neurodegenerative diseases

RD Wyse, GL Dunbar, J Rossignol - International journal of molecular …, 2014 - mdpi.com
The transplantation of mesenchymal stem cells (MSCs) for treating neurodegenerative
disorders has received growing attention recently because these cells are readily available …

Non-viral gene delivery to human mesenchymal stem cells: a practical guide towards cell engineering

N Carballo-Pedrares, F Ponti, J Lopez-Seijas… - Journal of Biological …, 2023 - Springer
In recent decades, human mesenchymal stem cells (hMSCs) have gained momentum in the
field of cell therapy for treating cartilage and bone injuries. Despite the tri-lineage …

Efficient nonviral transfection of human bone marrow mesenchymal stromal cells shown using placental growth factor overexpression

WY Cheung, O Hovey, JM Gobin… - Stem cells …, 2018 - Wiley Online Library
Background. Human mesenchymal stromal/stem cells (hMSCs) hold great therapeutic
potential due to their immunomodulatory and tissue regenerative properties. Enhancement …

Engineering of Human Mesenchymal Stem/Stromal Cells with Vascular Endothelial Growth Factor–Encoding Minicircles for Angiogenic Ex Vivo Gene Therapy

J Serra, CPA Alves, L Brito, GA Monteiro… - Human Gene …, 2019 - liebertpub.com
Peripheral artery disease (PAD) is a debilitating and prevalent condition characterized by
blockage of the arteries, leading to limb amputation in more severe cases. Mesenchymal …

Effective Gene Delivery into Human Stem Cells with a Cell‐Targeting Peptide‐Modified Bioreducible Polymer

J Beloor, S Ramakrishna, K Nam, C Seon Choi, J Kim… - Small, 2015 - Wiley Online Library
Stem cells are poorly permissive to non‐viral gene transfection reagents. In this study, we
explored the possibility of improving gene delivery into human embryonic (hESC) and …

Gene delivery in tissue engineering and regenerative medicine

YL Fang, XG Chen, G WT - Journal of Biomedical Materials …, 2015 - Wiley Online Library
As a promising strategy to aid or replace tissue/organ transplantation, gene delivery has
been used for regenerative medicine applications to create or restore normal function at the …

Possibilities and efficiency of MSC co-transfection for gene therapy

S Christoffers, L Seiler, E Wiebe, C Blume - Stem Cell Research & Therapy, 2024 - Springer
Mesenchymal stem/stromal cells (MSCs) are not only capable of self-renewal, trans-
differentiation, homing to damaged tissue sites and immunomodulation by secretion of …

Efficient cytosolic delivery mediated by polymersomes facilely prepared from a degradable, amphiphilic, and amphoteric copolymer

Z Huang, W Teng, L Liu, L Wang, Q Wang… - …, 2013 - iopscience.iop.org
To solve problems in polymersome preparation caused by liposolubility of copolymers and
to improve the cytosolic delivery efficiency of polymersomes to drugs, a lipopolysaccharide …

Transfection of CXCR-4 using microbubble-mediated ultrasound irradiation and liposomes improves the migratory ability of bone marrow stromal cells

G Wang, Z Zhuo, Q Zhang, Y Xu, S Wu, L Li… - Current Gene …, 2015 - ingentaconnect.com
Bone marrow stromal cells (BMSCs) have proven useful for the treatment of various human
diseases and injuries. However, their reparative capacity is limited by their poor migration …