Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors

A Gaurav, P Bakht, M Saini, S Pandey… - …, 2023 - microbiologyresearch.org
The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level.
The treatment options against infections caused by multiple drug-resistant bacteria are …

Physiological functions of bacterial “multidrug” efflux pumps

PJF Henderson, C Maher, LDH Elbourne… - Chemical …, 2021 - ACS Publications
Bacterial multidrug efflux pumps have come to prominence in human and veterinary
pathogenesis because they help bacteria protect themselves against the antimicrobials …

Enterotoxigenic Escherichia coli infection of weaned pigs: Intestinal challenges and nutritional intervention to enhance disease resistance

K Kim, M Song, Y Liu, P Ji - Frontiers in immunology, 2022 - frontiersin.org
Enterotoxigenic Escherichia coli (ETEC) infection induced post-weaning diarrhea is one of
the leading causes of morbidity and mortality in newly weaned pigs and one of the …

Efflux pump mediated antimicrobial resistance by staphylococci in health-related environments: challenges and the quest for inhibition

A Dashtbani-Roozbehani, MH Brown - Antibiotics, 2021 - mdpi.com
The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major
health threat worldwide due to significant morbidity and mortality resulting from their …

Impact of novel microbial secondary metabolites on the pharma industry

D Ramírez-Rendon, AK Passari, B Ruiz-Villafán… - Applied Microbiology …, 2022 - Springer
Microorganisms are remarkable producers of a wide diversity of natural products that
significantly improve human health and well-being. Currently, these natural products …

Inhibitory mechanisms of promising antimicrobials from plant byproducts: A review

M Qian, BB Ismail, Q He, X Zhang… - … Reviews in Food …, 2023 - Wiley Online Library
Plant byproducts and waste present enormous environmental challenges and an
opportunity for valorization and industrial application. Due to consumer demands for natural …

Cuminum cyminum L. Essential Oil: A Promising Antibacterial and Antivirulence Agent Against Multidrug-Resistant Staphylococcus aureus

A Sharifi, A Mohammadzadeh, TZ Salehi… - Frontiers in …, 2021 - frontiersin.org
Cuminum cyminum L.(cumin) is valued for its aromatic and medicinal properties. There are
several reports of antibacterial activity of C. cyminum essential oil (CcEO). Accordingly, the …

Potential of African medicinal plants against Enterobacteria: Classification of plants antibacterial agents

V Kuete - Advances in Botanical Research, 2023 - Elsevier
In the present chapter, the synopsis of active botanicals and phytochemicals of the flora of
Africa against drug-sensitive and drug-resistant strains of bacteria of the Enterobacteriaceae …

Tackling multidrug-resistant Staphylococcus aureus by natural products and their analogues acting as NorA efflux pump inhibitors

G Kumar, AK Tudu - Bioorganic & Medicinal Chemistry, 2023 - Elsevier
Staphylococcus aureus (S. aureus) is a pathogen responsible for various community and
hospital-acquired infections with life-threatening complications like bacteraemia …

Efflux pump inhibitors in controlling antibiotic resistance: outlook under a heavy metal contamination context

THT Nguyen, HD Nguyen, MH Le, TTH Nguyen… - Molecules, 2023 - mdpi.com
Multi-drug resistance to antibiotics represents a growing challenge in treating infectious
diseases. Outside the hospital, bacteria with the multi-drug resistance (MDR) phenotype …