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Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration
Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …
Intracellular Ca2+ signalling: unexpected new roles for the usual suspect
Cytosolic Ca2+ signals are organized in complex spatial and temporal patterns that underlie
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …
their unique ability to regulate multiple cellular functions. Changes in intracellular Ca2+ …
Proteomic analysis links alterations of bioenergetics, mitochondria-ER interactions and proteostasis in hippocampal astrocytes from 3xTg-AD mice
The pathogenesis of Alzheimer's disease (AD), a slowly-develo** age-related
neurodegenerative disorder, is a result of the action of multiple factors including …
neurodegenerative disorder, is a result of the action of multiple factors including …
Protein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer's disease mouse model: a role for ER-mitochondria interaction
Deregulation of protein synthesis and ER stress/unfolded protein response (ER stress/UPR)
have been reported in astrocytes. However, the relationships between protein synthesis …
have been reported in astrocytes. However, the relationships between protein synthesis …
Extracellular vesicles from 3xTg-AD mouse and Alzheimer's disease patient astrocytes impair neuroglial and vascular components
Astrocytes are specialized glial cells that are essential components of the neurovascular unit
(NVU) and are involved in neurodevelopment, brain maintenance and repair, and …
(NVU) and are involved in neurodevelopment, brain maintenance and repair, and …
Human hippocampal astrocytes: Computational dissection of their transcriptome, sexual differences and exosomes across ageing and mild‐cognitive impairment
DV Guebel - European Journal of Neuroscience, 2023 - Wiley Online Library
The role of astrocytes in Alzheimer's disease is often disregarded. Hence, characterization of
astrocytes along their early evolution toward Alzheimer would be greatly beneficial …
astrocytes along their early evolution toward Alzheimer would be greatly beneficial …
[HTML][HTML] Neuronal activity-dependent activation of astroglial calcineurin in mouse primary hippocampal cultures
Astrocytes respond to neuronal activity by generating calcium signals which are implicated
in the regulation of astroglial housekee** functions and/or in modulation of synaptic …
in the regulation of astroglial housekee** functions and/or in modulation of synaptic …
Deletion of calcineurin from astrocytes reproduces proteome signature of Alzheimer's disease and epilepsy and predisposes to seizures
Calcineurin (CaN), acting downstream of intracellular calcium signals, orchestrates cellular
remodeling in many cellular types. In astrocytes, major homeostatic players in the central …
remodeling in many cellular types. In astrocytes, major homeostatic players in the central …