The incidence and prevalence of type 2 diabetes mellitus (T2DM) in young individuals
(aged< 40 years) have significantly increased in recent years, approximating two to threefold …

The American Diabetes Association (ADA)“Standards of Care in Diabetes” includes the
ADA's current clinical practice recommendations and is intended to provide the components …

Maturity-onset diabetes of the young (MODY) is a spectrum of clinically heterogenous forms
of monogenic diabetes mellitus characterized by autosomal dominant inheritance, onset at a …

Background Monogenic diabetes presents opportunities for precision medicine but is
underdiagnosed. This review systematically assessed the evidence for (1) clinical criteria …

Background Beta-cell monogenic forms of diabetes have strong support for precision
medicine. We systematically analyzed evidence for precision treatments for GCK-related …

Context In the last decade the Sanger method of DNA sequencing has been replaced by
next-generation sequencing (NGS). NGS is valuable in conditions characterized by high …

Objective Heterozygous coding sequence mutations of the INS gene are a cause of
permanent neonatal diabetes (PNDM), requiring insulin therapy similar to T1D. While the …

As our understanding of the pathophysiology of diabetes evolves, we increasingly recognize
that many patients may have a form of diabetes that does not neatly fit with a diagnosis of …

Maturity-onset diabetes of the young (MODY) is an uncommon monogenic type of diabetes
mellitus. Detecting genetic variants for MODY is a necessity for precise diagnosis and …

Background Imprinting disorders are rare diseases resulting from altered expression of
imprinted genes, which exhibit parent-of-origin-specific expression patterns regulated …