A virtual patient simulation modeling the neural and perceptual effects of human visual cortical stimulation, from pulse trains to percepts

I Fine, GM Boynton - Scientific Reports, 2024 - nature.com
The field of cortical sight restoration prostheses is making rapid progress with three clinical
trials of visual cortical prostheses underway. However, as yet, we have only limited insight …

Avoidance of axonal stimulation with sinusoidal epiretinal stimulation

A Corna, AE Cojocaru, MT Bui… - Journal of Neural …, 2024 - iopscience.iop.org
Objective. Neuromodulation, particularly electrical stimulation, necessitates high spatial
resolution to achieve artificial vision with high acuity. In epiretinal implants, this is hindered …

Decoding dynamic visual scenes across the brain hierarchy

Y Chen, P Beech, Z Yin, S Jia, J Zhang… - PLOS Computational …, 2024 - journals.plos.org
Understanding the computational mechanisms that underlie the encoding and decoding of
environmental stimuli is a crucial investigation in neuroscience. Central to this pursuit is the …

Precise control of neural activity using dynamically optimized electrical stimulation

NP Shah, AJ Phillips, S Madugula, A Lotlikar… - Elife, 2024 - elifesciences.org
Neural implants have the potential to restore lost sensory function by electrically evoking the
complex naturalistic activity patterns of neural populations. However, it can be difficult to …

Understanding responses to multi-electrode epiretinal stimulation using a biophysical model

R Vilkhu, P Vasireddy, KE Kish… - Journal of Neural …, 2024 - iopscience.iop.org
Objective. Neural interfaces are designed to evoke specific patterns of electrical activity in
populations of neurons by stimulating with many electrodes. However, currents passed …

[HTML][HTML] Virtual Human Retina: Simulating Neural Signalling, Degeneration, and Responses to Electrical Stimulation

K Ly, ML Italiano, MN Shivdasani, D Tsai, JY Zhang… - Brain Stimulation, 2025 - Elsevier
Introduction Current brain-based visual prostheses pose significant challenges impeding
adoption such as the necessarily complex surgeries and occurrence of more substantial …

Comparison of modulation efficiency between normal and degenerated primate retina

Y Yoo, S Cha, YS Goo - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
With electrical stimulation, retinal prostheses bypass dysfunctional photoreceptors and
activate the surviving bipolar or retinal ganglion cells (RGCs). Therefore, the effective …

Spike sorting in the presence of stimulation artifacts: a dynamical control systems approach

M Shokri, AR Gogliettino, P Hottowy… - Journal of Neural …, 2024 - iopscience.iop.org
Objective. Bi-directional electronic neural interfaces, capable of both electrical recording and
stimulation, communicate with the nervous system to permit precise calibration of electrical …

Short pulse epiretinal stimulation allows focal activation of retinal ganglion cells

LX Koppenwallner, G Zeck… - IEEE Transactions on …, 2025 - ieeexplore.ieee.org
Epiretinal implants suffer from a lack of spatial resolution, which is greatly influenced by the
undesired co-activation of distal cells with their axons passing close to targeted somas …

Deep Learning for Visual Neuroprosthesis

P Beech, S Jia, Z Yu, JK Liu - arxiv preprint arxiv:2401.03639, 2024 - arxiv.org
The visual pathway involves complex networks of cells and regions which contribute to the
encoding and processing of visual information. While some aspects of visual perception are …