Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …

Brain circuits undergo substantial structural changes during development, driven by the
formation, stabilization, and elimination of synapses. Synaptic connections continue to …

Cortical state, defined by population-level neuronal activity patterns, determines sensory
perception. While arousal-associated neuromodulators—including norepinephrine (NE) …

Astrocytes negatively impact neuronal development in many models of neurodevelopmental
disorders (NDs); however, how they do this, and if mechanisms are shared across disorders …

Astrocytes, the most abundant non-neuronal cell type in the mammalian brain, are crucial
circuit components that respond to and modulate neuronal activity through calcium (Ca2+) …

Astrocytes are non-neuronal cells that regulate synapses, neuronal circuits, and behavior.
Astrocytes ensheath neuronal synapses to form the tripartite synapse where astrocytes …

Astrocytes are ubiquitous within the central nervous system (CNS). These cells possess
many individual processes which extend out into the neuropil, where they interact with a …

Astrocytes play an integral role in the development, maturation, and refinement of neuronal
circuits. Astrocytes secrete proteins and lipids that instruct the formation of new synapses …

Communication between neurons and glia has an important role in establishing and
maintaining higher-order brain function. Astrocytes are endowed with complex …

Neuronal activity drives alterations in gene expression within neurons, yet how it directs
transcriptional and epigenomic changes in neighboring astrocytes in functioning circuits is …