The dynamic ion motive force powering the bacterial flagellar motor

A Biquet-Bisquert, G Labesse, F Pedaci… - Frontiers in …, 2021 - frontiersin.org
The bacterial flagellar motor (BFM) is a rotary molecular motor embedded in the cell
membrane of numerous bacteria. It turns a flagellum which acts as a propeller, enabling …

Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit

H Hu, PF Popp, M Santiveri, A Roa-Eguiara… - Nature …, 2023 - nature.com
Bacteria swim using a flagellar motor that is powered by stator units. Vibrio spp. are highly
motile bacteria responsible for various human diseases, the polar flagella of which are …

Tuning the stator subunit of the flagellar motor with coiled‐coil engineering

P Ridone, DL Winter, MAB Baker - Protein Science, 2023 - Wiley Online Library
Many bacteria swim driven by an extracellular filament rotated by the bacterial flagellar
motor. This motor is powered by the stator complex, MotA5MotB2, an heptameric complex …

Hybrid Exb/Mot stators require substitutions distant from the chimeric pore to power flagellar rotation

P Ridone, MAB Baker - Journal of Bacteriology, 2024 - journals.asm.org
Powered by ion transport across the cell membrane, conserved ion-powered rotary motors
(IRMs) drive bacterial motility by generating torque on the rotor of the bacterial flagellar …

Ancestral reconstruction of the MotA stator subunit reveals that conserved residues far from the pore are required to drive flagellar motility

MI Islam, P Ridone, A Lin, KA Michie, NJ Matzke… - MicroLife, 2023 - academic.oup.com
The bacterial flagellar motor (BFM) is a rotary nanomachine powered by the translocation of
ions across the inner membrane through the stator complex. The stator complex consists of …

Novel amiloride derivatives that inhibit bacterial motility across multiple strains and stator types

MI Islam, JH Bae, T Ishida, P Ridone, J Lin… - Journal of …, 2021 - journals.asm.org
The bacterial flagellar motor (BFM) is a protein complex that confers motility to cells and
contributes to survival and virulence. The BFM consists of stators that are ion-selective …

[PDF][PDF] Allosteric adaptation in the stator complex rescues bacterial motility in Exb/Mot chimeras

P Ridone, MAB Baker - bioRxiv, 2024 - researchgate.net
Powered by ion transport across the cell membrane, conserved ion-powered rotary motors
(IRMs) drive bacterial motility by generating torque on the rotor of the bacterial flagellar …

The rapid evolution of flagellar ion selectivity in experimental populations of E. coli

P Ridone, T Ishida, A Lin, DT Humphreys… - Science …, 2022 - science.org
Determining which cellular processes facilitate adaptation requires a tractable experimental
model where an environmental cue can generate variants that rescue function. The bacterial …

Ion-powered rotary motors: where did they come from and where they are going?

V Nandel, J Scadden, MAB Baker - International Journal of Molecular …, 2023 - mdpi.com
Molecular motors are found in many living organisms. One such molecular machine, the ion-
powered rotary motor (IRM), requires the movement of ions across a membrane against a …

Easy come, easier go: map** the loss of flagellar motility across the tree of life

JS Philip, S Grewal, J Scadden, C Puente Lelievre… - bioRxiv, 2024 - biorxiv.org
Most bacterial swimming is powered by the bacterial flagellar motor, a nanomachine that self-
assembles from up to 45 proteins into a membrane-spanning complex. The number and …