Even though cancer treatment has improved over the recent decades, still more specific and
effective treatment concepts are mandatory. Surgical removal is not always possible …

Microtubules, major structural components in cells, are the target of a large and diverse
group of natural product anticancer drugs. Given the success of this class of drugs in cancer …

Cells that cannot satisfy the spindle assembly checkpoint (SAC) are delayed in mitosis (D-
mitosis), a fact that has useful clinical ramifications. However, this delay is seldom …

Microtubules and actin filaments play important roles in mitosis, cell signaling, and motility.
Thus these cytoskeletal filaments are the targets of a growing number of anti-cancer drugs …

Dendritic spines are the major sites of excitatory synaptic input, and their morphological
changes have been linked to learning and memory processes. Here, we report that growing …

Microtubules are intrinsically dynamic polymers, and their dynamics play a crucial role in
mitotic spindle assembly, the mitotic checkpoint, and chromosome movement. We …

Mitochondria display complex morphology and movements, which complicates their
segmentation and tracking in time-lapse images. Here, we introduce Mitometer, an algorithm …

Axon formation is the initial step in establishing neuronal polarity. We examine here the role
of microtubule dynamics in neuronal polarization using hippocampal neurons in culture. We …

Mechanosensitive ion channels convert mechanical stimuli into a flow of ions. These
channels are widely distributed from bacteria to higher plants and humans, and are involved …

E7389, which is in phase I and II clinical trials, is a synthetic macrocyclic ketone analogue of
the marine sponge natural product halichondrin B. Whereas its mechanism of action has not …