The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances

P Saraei, I Asadi, MA Kakar… - Cancer management and …, 2019 - Taylor & Francis
Metformin is a widely used drug in today's prescriptions by physicians due to its specific
effects in treating and curing type II diabetes. Diabetes is a common disease that may occur …

Targeting AMPK for cancer prevention and treatment

W Li, SM Saud, MR Young, G Chen, B Hua - Oncotarget, 2015 - pmc.ncbi.nlm.nih.gov
AMP-activated protein kinase (AMPK) is an important mediator in maintaining cellular
energy homeostasis. AMPK is activated in response to a shortage of energy. Once activated …

Dissecting the dual role of AMPK in cancer: from experimental to human studies

G Zadra, JL Batista, M Loda - Molecular cancer research, 2015 - aacrjournals.org
The precise role of 5′ AMP-activated kinase (AMPK) in cancer and its potential as a
therapeutic target is controversial. Although it is well established that activation of this …

[HTML][HTML] Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect

L Zhu, K Yang, Z Ren, D Yin, Y Zhou - Translational oncology, 2024 - Elsevier
Metformin, as the preferred antihyperglycemic drug for type 2 diabetes, has been found to
have a significant effect in inhibiting tumor growth in recent years. However, metformin alone …

Metformin targets multiple signaling pathways in cancer

Y Lei, Y Yi, Y Liu, X Liu, ET Keller, CN Qian… - Chinese journal of …, 2017 - Springer
Metformin, an inexpensive and well-tolerated oral agent commonly used in the first-line
treatment of type 2 diabetes, has become the focus of intense research as a candidate …

Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production

A Mogavero, MV Maiorana, S Zanutto, L Varinelli… - Scientific reports, 2017 - nature.com
Metformin is a widely used and well-tolerated anti-diabetic drug that can reduce cancer risk
and improve the prognosis of certain malignancies. However, the mechanism underlying its …

Metformin enhances anti-cancer properties of resveratrol in MCF-7 breast cancer cells via induction of apoptosis, autophagy and alteration in cell cycle distribution

R Fatehi, M Rashedinia, AR Akbarizadeh… - Biochemical and …, 2023 - Elsevier
Breast cancer is the fifth leading cause of death, worldwide affecting both genders.
Accumulating evidence suggests that metformin, an oral hypoglycemic agent used in the …

Oncogene-driven metabolic alterations in cancer

HY Min, HY Lee - Biomolecules & therapeutics, 2017 - pmc.ncbi.nlm.nih.gov
Cancer is the leading cause of human deaths worldwide. Understanding the biology
underlying the evolution of cancer is important for reducing the economic and social burden …

Metformin: a novel biological modifier of tumor response to radiation therapy

M Koritzinsky - International Journal of Radiation Oncology* Biology …, 2015 - Elsevier
Over the last decade, evidence has emerged to support a role for the antidiabetic drug
metformin in the prevention and treatment of cancer. In particular, recent studies …

Metformin as a radiation modifier; implications to normal tissue protection and tumor sensitization

K Mortezaee, D Shabeeb, AE Musa… - Current clinical …, 2019 - ingentaconnect.com
Background: Nowadays, ionizing radiation is used for several applications in medicine,
industry, agriculture, and nuclear power generation. Besides the beneficial roles of ionizing …