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The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances
Metformin is a widely used drug in today's prescriptions by physicians due to its specific
effects in treating and curing type II diabetes. Diabetes is a common disease that may occur …
effects in treating and curing type II diabetes. Diabetes is a common disease that may occur …
Targeting AMPK for cancer prevention and treatment
AMP-activated protein kinase (AMPK) is an important mediator in maintaining cellular
energy homeostasis. AMPK is activated in response to a shortage of energy. Once activated …
energy homeostasis. AMPK is activated in response to a shortage of energy. Once activated …
Dissecting the dual role of AMPK in cancer: from experimental to human studies
G Zadra, JL Batista, M Loda - Molecular cancer research, 2015 - aacrjournals.org
The precise role of 5′ AMP-activated kinase (AMPK) in cancer and its potential as a
therapeutic target is controversial. Although it is well established that activation of this …
therapeutic target is controversial. Although it is well established that activation of this …
[HTML][HTML] Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect
L Zhu, K Yang, Z Ren, D Yin, Y Zhou - Translational oncology, 2024 - Elsevier
Metformin, as the preferred antihyperglycemic drug for type 2 diabetes, has been found to
have a significant effect in inhibiting tumor growth in recent years. However, metformin alone …
have a significant effect in inhibiting tumor growth in recent years. However, metformin alone …
Metformin targets multiple signaling pathways in cancer
Y Lei, Y Yi, Y Liu, X Liu, ET Keller, CN Qian… - Chinese journal of …, 2017 - Springer
Metformin, an inexpensive and well-tolerated oral agent commonly used in the first-line
treatment of type 2 diabetes, has become the focus of intense research as a candidate …
treatment of type 2 diabetes, has become the focus of intense research as a candidate …
Metformin transiently inhibits colorectal cancer cell proliferation as a result of either AMPK activation or increased ROS production
A Mogavero, MV Maiorana, S Zanutto, L Varinelli… - Scientific reports, 2017 - nature.com
Metformin is a widely used and well-tolerated anti-diabetic drug that can reduce cancer risk
and improve the prognosis of certain malignancies. However, the mechanism underlying its …
and improve the prognosis of certain malignancies. However, the mechanism underlying its …
Metformin enhances anti-cancer properties of resveratrol in MCF-7 breast cancer cells via induction of apoptosis, autophagy and alteration in cell cycle distribution
Breast cancer is the fifth leading cause of death, worldwide affecting both genders.
Accumulating evidence suggests that metformin, an oral hypoglycemic agent used in the …
Accumulating evidence suggests that metformin, an oral hypoglycemic agent used in the …
Oncogene-driven metabolic alterations in cancer
HY Min, HY Lee - Biomolecules & therapeutics, 2017 - pmc.ncbi.nlm.nih.gov
Cancer is the leading cause of human deaths worldwide. Understanding the biology
underlying the evolution of cancer is important for reducing the economic and social burden …
underlying the evolution of cancer is important for reducing the economic and social burden …
Metformin: a novel biological modifier of tumor response to radiation therapy
M Koritzinsky - International Journal of Radiation Oncology* Biology …, 2015 - Elsevier
Over the last decade, evidence has emerged to support a role for the antidiabetic drug
metformin in the prevention and treatment of cancer. In particular, recent studies …
metformin in the prevention and treatment of cancer. In particular, recent studies …
Metformin as a radiation modifier; implications to normal tissue protection and tumor sensitization
K Mortezaee, D Shabeeb, AE Musa… - Current clinical …, 2019 - ingentaconnect.com
Background: Nowadays, ionizing radiation is used for several applications in medicine,
industry, agriculture, and nuclear power generation. Besides the beneficial roles of ionizing …
industry, agriculture, and nuclear power generation. Besides the beneficial roles of ionizing …