The role of ultrasound-driven microbubble dynamics in drug delivery: from microbubble fundamentals to clinical translation

S Roovers, T Segers, G Lajoinie, J Deprez, M Versluis… - Langmuir, 2019 - ACS Publications
In the last couple of decades, ultrasound-driven microbubbles have proven excellent
candidates for local drug delivery applications. Besides being useful drug carriers …

Nucleation, map** and control of cavitation for drug delivery

E Stride, C Coussios - Nature Reviews Physics, 2019 - nature.com
Acoustically driven bubbles produce a range of mechanical, thermal and chemical effects
that can be exploited in drug delivery applications. Significant improvements in the targeting …

Ultrasound‐propelled nanocups for drug delivery

JJ Kwan, R Myers, CM Coviello, SM Graham, AR Shah… - small, 2015 - Wiley Online Library
Ultrasound‐induced bubble activity (cavitation) has been recently shown to actively
transport and improve the distribution of therapeutic agents in tumors. However, existing …

Quantitative frequency-domain passive cavitation imaging

KJ Haworth, KB Bader, KT Rich… - IEEE transactions on …, 2016 - ieeexplore.ieee.org
Passive cavitation detection has been an instrumental technique for measuring cavitation
dynamics, elucidating concomitant bioeffects, and guiding ultrasound therapies. Recently …

Passive acoustic map** utilizing optimal beamforming in ultrasound therapy monitoring

C Coviello, R Kozick, J Choi, M Gyöngy… - The Journal of the …, 2015 - pubs.aip.org
Passive acoustic map** (PAM) is a promising imaging method that enables real-time
three-dimensional monitoring of ultrasound therapy through the reconstruction of acoustic …

Nucleic acid delivery with microbubbles and ultrasound

JJ Rychak, AL Klibanov - Advanced drug delivery reviews, 2014 - Elsevier
Nucleic acid-based therapy is a growing field of drug delivery research. Although ultrasound
has been suggested to enhance transfection decades ago, it took a combination of …

Review of ultrasound mediated drug delivery for cancer treatment: updates from pre-clinical studies

O Couture, J Foley, NF Kassell, B Larrat… - Translational Cancer …, 2014 - tcr.amegroups.org
Therapeutic ultrasound has been used to thermally ablate solid tumors since the 90s, and a
variety of cancers are presently being treated clinically, taking advantage of ultrasound-or …

Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound

R Carlisle, J Choi, M Bazan-Peregrino… - Journal of the …, 2013 - academic.oup.com
Background Oncolytic viruses are among the most powerful and selective cancer
therapeutics under development and are showing robust activity in clinical trials, particularly …

Ultrasound-induced inertial cavitation from gas-stabilizing nanoparticles

JJ Kwan, S Graham, R Myers, R Carlisle, E Stride… - Physical Review E, 2015 - APS
The understanding of cavitation from nanoparticles has been hindered by the inability to
control nanobubble size. We present a method to manufacture nanoparticles with a tunable …

Ultrasound-targeted microbubble destruction: modulation in the tumor microenvironment and application in tumor immunotherapy

Y Han, J Sun, H Wei, J Hao, W Liu, X Wang - Frontiers in immunology, 2022 - frontiersin.org
Tumor immunotherapy has shown strong therapeutic potential for stimulating or
reconstructing the immune system to control and kill tumor cells. It is a promising and …