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The role of ultrasound-driven microbubble dynamics in drug delivery: from microbubble fundamentals to clinical translation
In the last couple of decades, ultrasound-driven microbubbles have proven excellent
candidates for local drug delivery applications. Besides being useful drug carriers …
candidates for local drug delivery applications. Besides being useful drug carriers …
Nucleation, map** and control of cavitation for drug delivery
Acoustically driven bubbles produce a range of mechanical, thermal and chemical effects
that can be exploited in drug delivery applications. Significant improvements in the targeting …
that can be exploited in drug delivery applications. Significant improvements in the targeting …
Ultrasound‐propelled nanocups for drug delivery
JJ Kwan, R Myers, CM Coviello, SM Graham, AR Shah… - small, 2015 - Wiley Online Library
Ultrasound‐induced bubble activity (cavitation) has been recently shown to actively
transport and improve the distribution of therapeutic agents in tumors. However, existing …
transport and improve the distribution of therapeutic agents in tumors. However, existing …
Quantitative frequency-domain passive cavitation imaging
Passive cavitation detection has been an instrumental technique for measuring cavitation
dynamics, elucidating concomitant bioeffects, and guiding ultrasound therapies. Recently …
dynamics, elucidating concomitant bioeffects, and guiding ultrasound therapies. Recently …
Passive acoustic map** utilizing optimal beamforming in ultrasound therapy monitoring
Passive acoustic map** (PAM) is a promising imaging method that enables real-time
three-dimensional monitoring of ultrasound therapy through the reconstruction of acoustic …
three-dimensional monitoring of ultrasound therapy through the reconstruction of acoustic …
Nucleic acid delivery with microbubbles and ultrasound
JJ Rychak, AL Klibanov - Advanced drug delivery reviews, 2014 - Elsevier
Nucleic acid-based therapy is a growing field of drug delivery research. Although ultrasound
has been suggested to enhance transfection decades ago, it took a combination of …
has been suggested to enhance transfection decades ago, it took a combination of …
Review of ultrasound mediated drug delivery for cancer treatment: updates from pre-clinical studies
O Couture, J Foley, NF Kassell, B Larrat… - Translational Cancer …, 2014 - tcr.amegroups.org
Therapeutic ultrasound has been used to thermally ablate solid tumors since the 90s, and a
variety of cancers are presently being treated clinically, taking advantage of ultrasound-or …
variety of cancers are presently being treated clinically, taking advantage of ultrasound-or …
Enhanced tumor uptake and penetration of virotherapy using polymer stealthing and focused ultrasound
Background Oncolytic viruses are among the most powerful and selective cancer
therapeutics under development and are showing robust activity in clinical trials, particularly …
therapeutics under development and are showing robust activity in clinical trials, particularly …
Ultrasound-induced inertial cavitation from gas-stabilizing nanoparticles
The understanding of cavitation from nanoparticles has been hindered by the inability to
control nanobubble size. We present a method to manufacture nanoparticles with a tunable …
control nanobubble size. We present a method to manufacture nanoparticles with a tunable …
Ultrasound-targeted microbubble destruction: modulation in the tumor microenvironment and application in tumor immunotherapy
Y Han, J Sun, H Wei, J Hao, W Liu, X Wang - Frontiers in immunology, 2022 - frontiersin.org
Tumor immunotherapy has shown strong therapeutic potential for stimulating or
reconstructing the immune system to control and kill tumor cells. It is a promising and …
reconstructing the immune system to control and kill tumor cells. It is a promising and …