The role of the induction of oxidative stress as the mechanism of action of many antitumor
drugs is acquiring an increasing interest. In such cases, the antitumor therapy success may …

An increase in the levels of oxidation is a universal feature of genomic DNA of irradiated or
aged or even malignant cells. In case of apoptotic death of stressed cells, oxidized DNA can …

Aqueous solutions of highly stable supramolecular donor–acceptor complexes of chemically
nonmodified pristine C60 fullerene molecules with H2O molecules (hydrated C60 fullerene …

Background The broad spectrum of oxidative damage DNA biomarkers: urinary excretion of
8-oxodG (8-oxo-7, 8-dihydro-2′-deoxyguanosine), 8-oxoGua (8-oxo-7, 8-dihydroguanine) …

Mass spectrometry has been widely utilised in the study of nucleobases, nucleosides and
nucleotides as components of nucleic acids and as bioactive metabolites in their own right …

A highly sensitive quantitative method based on LC-MS/MS was developed to
simultaneously and directly measure 8-oxo-7, 8-dihydroguanine (8-oxoGua) and 8-oxo-7, 8 …

Oxidatively damaged DNA may be important in carcinogenesis. 8-Oxo-7, 8-dihydroguanine
(8-oxoGua) is an abundant and mutagenic lesion excised by oxoguanine DNA glycosylase …

A large-scale nuclear event has the ability to inflict mass casualties requiring point-of-care
and laboratory-based diagnostic and prognostic biomarkers to inform victim triage and …

COVID-19 is a challenge to biosecurity and public health. The speed of vaccine
development lags behind that of virus evolution and mutation. To date, no agent has been …

Metabolomics on easily accessible biofluids has the potential to provide rapid identification
and distinction between stressors and inflammatory states. In the event of a radiological …