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[HTML][HTML] Machine learning approaches to genome-wide association studies
Abstract Genome-wide Association Studies (GWAS) are conducted to identify single
nucleotide polymorphisms (variants) associated with a phenotype within a specific …
nucleotide polymorphisms (variants) associated with a phenotype within a specific …
Pharmacogenetic panel testing: a review of current practice and potential for clinical implementation
Pharmacogenetics (PGx) aims to optimize drug treatment outcomes by using a patient's
genetic profile for individualized drug and dose selection. Currently, reactive and …
genetic profile for individualized drug and dose selection. Currently, reactive and …
AI can help to tailor drugs for Africa—but Africans should lead the way
Computational models that require very little data could transform biomedical and drug
development research in Africa, as long as infrastructure, trained staff and secure databases …
development research in Africa, as long as infrastructure, trained staff and secure databases …
Environmental toxicology in addressing public health challenges in Africa
Environmental toxicology is a diverse scientific discipline that is highly influential in the field
of toxicology, environmental health, and public policy. However, there is a paucity of data …
of toxicology, environmental health, and public policy. However, there is a paucity of data …
Advancing pharmacogenetics research in Africa: the “Project Africa GRADIENT” initiative
Africa is home to some of the most genetically diverse populations in the world, with a
population of over 1.2 billion people comprised of over 3,000 distinct ethnic groups and a …
population of over 1.2 billion people comprised of over 3,000 distinct ethnic groups and a …
The extent and impact of variation in ADME genes in sub-Saharan African populations
Introduction: Investigating variation in genes involved in the absorption, distribution,
metabolism, and excretion (ADME) of drugs are key to characterizing pharmacogenomic …
metabolism, and excretion (ADME) of drugs are key to characterizing pharmacogenomic …
From drug discovery to drug approval: a comprehensive review of the pharmacogenomics status quo with a special focus on Egypt
Pharmacogenomics (PGx) is the hope for the full optimization of drug therapy while
minimizing the accompanying adverse drug events that cost billions of dollars annually …
minimizing the accompanying adverse drug events that cost billions of dollars annually …
The role of pharmacogenomics studies for precision medicine among Ethiopian patients and their clinical implications: a sco** review
Background Pharmacogenomics research is currently revolutionizing treatment optimization
by discovering molecular markers. Medicines are the cornerstone of treatment for both acute …
by discovering molecular markers. Medicines are the cornerstone of treatment for both acute …
[HTML][HTML] Allostery and missense mutations as intermittently linked promising aspects of modern computational drug discovery
Drug research and development is a multidisciplinary field with its own successes. Yet,
given the complexity of the process, it also faces challenges over the long development …
given the complexity of the process, it also faces challenges over the long development …
Map** the pharmacogenetic landscape in a Ugandan population: implications for personalized medicine in an underrepresented population
Africans are extremely underrepresented in global genomic research. African populations
face high burdens of communicable and non‐communicable diseases and experience …
face high burdens of communicable and non‐communicable diseases and experience …