Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

Deubiquitinases (DUBs) are specialized proteases that remove ubiquitin from substrates or
cleave within ubiquitin chains to regulate ubiquitylation and therefore play important roles in …

Post-translational modifications such as ubiquitination play important regulatory roles in
several biological processes in eukaryotes. This process could be reversed by …

The importance of oxygen for the survival of multicellular and aerobic organisms is well
established and documented. Over the years, increased knowledge of its use for …

Significance: Limited oxygen availability (hypoxia) commonly occurs in a range of
physiological and pathophysiological conditions, including embryonic development …

Deubiquitination plays an important role in the regulation of the crosstalk between
macroautophagy/autophagy and innate immune signaling, yet its regulatory mechanisms …

Deubiquitinases (DUBs) are required for the reverse reaction of ubiquitination and act as
major regulators of ubiquitin signaling processes. Emerging evidence suggests that these …

Oxygen is essential for viability in mammalian organisms. However, cells are often exposed
to changes in oxygen availability, due to either increased demand or reduced oxygen …

The phylum Apicomplexa contains several parasitic species of medical and agricultural
importance. The ubiquitination machinery remains, for the most part, uncharacterised in …

Factor-inhibiting HIF (FIH) is an asparagine hydroxylase that acts on hypoxia-inducible
factors (HIFs) to control cellular adaptation to hypoxia. FIH is expressed in several tumor …