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DNA mismatch repair and the DNA damage response
Z Li, AH Pearlman, P Hsieh - DNA repair, 2016 - Elsevier
This review discusses the role of DNA mismatch repair (MMR) in the DNA damage response
(DDR) that triggers cell cycle arrest and, in some cases, apoptosis. Although the focus is on …
(DDR) that triggers cell cycle arrest and, in some cases, apoptosis. Although the focus is on …
DNA glycosylases: in DNA repair and beyond
The base excision repair machinery protects DNA in cells from the damaging effects of
oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form …
oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form …
Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors
Mutations in the BRCA1 or BRCA2 tumor suppressor genes predispose individuals to breast
and ovarian cancer. In the clinic, these cancers are treated with inhibitors that target poly …
and ovarian cancer. In the clinic, these cancers are treated with inhibitors that target poly …
Biochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism
AR Weber, C Krawczyk, AB Robertson… - Nature …, 2016 - nature.com
Cytosine methylation in CpG dinucleotides is an epigenetic DNA modification dynamically
established and maintained by DNA methyltransferases and demethylases. Molecular …
established and maintained by DNA methyltransferases and demethylases. Molecular …
Microsatellite instability as a marker of prognosis and response to therapy: a meta-analysis of colorectal cancer survival data
BACKGROUND AND METHODS: We have reviewed and pooled data from published
studies to evaluate the relationship between microsatellite instability (MSI) and colorectal …
studies to evaluate the relationship between microsatellite instability (MSI) and colorectal …
Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability
Thymine DNA glycosylase (TDG) is a member of the uracil DNA glycosylase (UDG)
superfamily of DNA repair enzymes. Owing to its ability to excise thymine when mispaired …
superfamily of DNA repair enzymes. Owing to its ability to excise thymine when mispaired …
A comprehensive survey of the mutagenic impact of common cancer cytotoxics
Background Genomic mutations caused by cytotoxic agents used in cancer chemotherapy
may cause secondary malignancies as well as contribute to the evolution of treatment …
may cause secondary malignancies as well as contribute to the evolution of treatment …
A novel view on an old drug, 5-fluorouracil: an unexpected RNA modifier with intriguing impact on cancer cell fate
Fluorouracil (5-FU) is a chemotherapeutic drug widely used to treat patients with solid
tumours, such as colorectal and pancreatic cancers. Colorectal cancer (CRC) is the second …
tumours, such as colorectal and pancreatic cancers. Colorectal cancer (CRC) is the second …
TAS-102, a novel antitumor agent: a review of the mechanism of action
Inhibition of nucleoside metabolism is an important principle in cancer therapy as evidenced
by the role of fluoropyrimidines, such as 5-fluorouracil (5-FU), and antifolates in the …
by the role of fluoropyrimidines, such as 5-fluorouracil (5-FU), and antifolates in the …
[HTML][HTML] Base editing in plants: current status and challenges
SS Bharat, S Li, J Li, L Yan, L **a - The Crop Journal, 2020 - Elsevier
Genome editing technologies have revolutionized the field of plant science by enabling
targeted modification of plant genomes and are emerging as powerful tools for both plant …
targeted modification of plant genomes and are emerging as powerful tools for both plant …