[HTML][HTML] The involvement of the Wnt/β-catenin signaling cascade in fibrosis progression and its therapeutic targeting by relaxin

DVN Somanader, P Zhao, RE Widdop… - Biochemical …, 2024 - Elsevier
Organ scarring, referred to as fibrosis, results from a failed wound-healing response to
chronic tissue injury and is characterised by the aberrant accumulation of various …

TGF-β-based therapies for treating ocular surface disorders

FT Ogata, S Verma, VJ Coulson-Thomas, TF Gesteira - Cells, 2024 - mdpi.com
The cornea is continuously exposed to injuries, ranging from minor scratches to deep
traumas. An effective healing mechanism is crucial for the cornea to restore its structure and …

Thyroid-associated ophthalmopathy: the role of oxidative stress

C Ma, H Li, S Lu, X Li - Frontiers in Endocrinology, 2024 - frontiersin.org
Thyroid-associated ophthalmopathy (TAO) is an autoimmune condition affecting the eyes,
characterized by proptosis, extraocular muscle involvement, and in severe cases, vision …

Botulinum neurotoxin induces neurotoxic microglia mediated by exogenous inflammatory responses

G Ambrin, YJ Kang, K Van Do, C Lee… - Advanced …, 2024 - Wiley Online Library
Botulinum neurotoxin serotype A (BoNT/A) is widely used in therapeutics and cosmetics.
The effects of multi‐dosed BoNT/A treatment are well documented on the peripheral nervous …

Thyroid-associated ophthalmopathy and ferroptosis: a review of pathological mechanisms and therapeutic strategies

C Ma, H Li, S Lu, X Li - Frontiers in Immunology, 2024 - frontiersin.org
Thyroid-associated ophthalmopathy (TAO) is an inflammatory orbital disease associated
with autoimmune thyroid disorders. Owing to the ambiguous nature of the pathogenesis …

[HTML][HTML] A review of pathophysiology and therapeutic strategies targeting TGF-β in Graves' ophthalmopathy

HH Chang, SB Wu, CC Tsai - Cells, 2024 - mdpi.com
TGF-β plays a pivotal role in the pathogenesis of GO by promoting orbital tissue remodeling
and fibrosis. This process involves the stimulation of orbital fibroblasts, leading to …

Low-level laser therapy in the treatment of autoimmune thyroiditis

N Hossein-Khannazer, MK Arki… - Journal of Lasers in …, 2022 - pmc.ncbi.nlm.nih.gov
Introduction: Autoimmune thyroiditis (AIT) is an autoimmune disorder that is characterized by
thyroid gland dysfunction. Low-level laser therapy (LLLT), as a safe and non-invasive …

Exposure of Akwesasne Mohawk women to polychlorinated biphenyls and hexachlorobenzene is associated with increased serum levels of thyroid peroxidase …

F Lee, MV Gallo, LM Schell, J Jennings… - Journal of Toxicology …, 2023 - Taylor & Francis
Persistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs),
hexachlorobenzene (HCB), and dichlorodiphenyltrichloroethane (p, p'-DDT) were reported …

Evaluation of epithelial–mesenchymal transition markers in autoimmune thyroid diseases

P Sacristán-Gómez, A Serrano-Somavilla… - International Journal of …, 2023 - mdpi.com
A state of chronic inflammation is common in organs affected by autoimmune disorders,
such as autoimmune thyroid diseases (AITD). Epithelial cells, such as thyroid follicular cells …

[HTML][HTML] Трансформирующий фактор роста β1 (TGF-β1) у пациентов с эндокринной офтальмопатией и болезнью Грейвса-предиктор эффективности лечения

НЮ Свириденко, ЕГ Бессмертная… - Медицинская …, 2022 - cyberleninka.ru
Существующие терапевтические подходы к лечению эндокринной офтальмопатии
(ЭОП) основываются на неспецифической иммуносупрессии глюкокортикоидами (ГК) и …