The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: Implications for emerging pharmacotherapies aiming at fat reduction and lean …
Incretin receptor agonists have revolutionized the treatment of obesity, achieving up to 15–
25% weight loss in many patients, ie, at a rate approaching that achieved with bariatric …
25% weight loss in many patients, ie, at a rate approaching that achieved with bariatric …
Myostatin: Basic biology to clinical application
P Esposito, D Picciotto, Y Battaglia, F Costigliolo… - Advances in clinical …, 2022 - Elsevier
Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …
by animal and human skeletal muscle cells where it limits muscle growth and promotes …
Effects of elastic band resistance training and nutritional supplementation on muscle quality and circulating muscle growth and degradation factors of institutionalized …
M Hofmann, B Schober-Halper, S Oesen… - European journal of …, 2016 - Springer
Purpose Regular resistance exercise training and a balanced diet may counteract the age-
related muscular decline on a molecular level. The aim of this study was to investigate the …
related muscular decline on a molecular level. The aim of this study was to investigate the …
Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay
HR Bergen, JN Farr, PM Vanderboom, EJ Atkinson… - Skeletal muscle, 2015 - Springer
Background Myostatin is a protein synthesized and secreted by skeletal muscle that
negatively regulates muscle mass. The extent to which circulating myostatin levels change …
negatively regulates muscle mass. The extent to which circulating myostatin levels change …
Myostatin and muscle atrophy during chronic kidney disease
S Bataille, P Chauveau, D Fouque… - Nephrology Dialysis …, 2021 - academic.oup.com
Chronic kidney disease (CKD) patients often exhibit a low muscle mass and strength,
leading to physical impairment and an increased mortality. Two major signalling pathways …
leading to physical impairment and an increased mortality. Two major signalling pathways …
The role of primary cilia in the development and disease of the retina
The normal development and function of photoreceptors is essential for eye health and
visual acuity in vertebrates. Mutations in genes encoding proteins involved in photoreceptor …
visual acuity in vertebrates. Mutations in genes encoding proteins involved in photoreceptor …
The vicious cycle of myostatin signaling in sarcopenic obesity: myostatin role in skeletal muscle growth, insulin signaling and implications for clinical trials
The age-related loss of skeletal muscle (sarcopenia) is a major health concern as it is
associated with physical disability, metabolic impairments, and increased mortality. The …
associated with physical disability, metabolic impairments, and increased mortality. The …
Skeletal muscle mass adjusted by height correlated better with muscular functions than that adjusted by body weight in defining sarcopenia
Sarcopenia, characterized by low muscle mass and function, results in frailty, comorbidities
and mortality. However, its prevalence varies according to the different criteria used in its …
and mortality. However, its prevalence varies according to the different criteria used in its …
Muscle wasting in chronic kidney disease: mechanism and clinical implications—a narrative review
TC Cheng, SH Huang, CL Kao, PC Hsu - International Journal of …, 2022 - mdpi.com
Muscle wasting, known to develop in patients with chronic kidney disease (CKD), is a
deleterious consequence of numerous complications associated with deteriorated renal …
deleterious consequence of numerous complications associated with deteriorated renal …
Therapies for musculoskeletal disease: can we treat two birds with one stone?
CM Girgis, N Mokbel, DJ DiGirolamo - Current osteoporosis reports, 2014 - Springer
Musculoskeletal diseases are highly prevalent with staggering annual health care costs
across the globe. The combined wasting of muscle (sarcopenia) and bone (osteoporosis) …
across the globe. The combined wasting of muscle (sarcopenia) and bone (osteoporosis) …