Targeting apoptosis in cancer therapy
BA Carneiro, WS El-Deiry - Nature reviews Clinical oncology, 2020 - nature.com
For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …
of therapies promoting the effective elimination of cancer cells by apoptosis. This …
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
The tumour suppressor gene TP53 is mutated in~ 50% of human cancers. In addition to its
function in tumour suppression, p53 also plays a major role in the response of malignant as …
function in tumour suppression, p53 also plays a major role in the response of malignant as …
[HTML][HTML] Cell death in the origin and treatment of cancer
A Strasser, DL Vaux - Molecular cell, 2020 - cell.com
Cell death, or, more specifically, cell suicide, is a process of fundamental importance to
human health. Throughout our lives, over a million cells are produced every second. When …
human health. Throughout our lives, over a million cells are produced every second. When …
Should mutant TP53 be targeted for cancer therapy?
Z Wang, A Strasser, GL Kelly - Cell Death & Differentiation, 2022 - nature.com
Mutations in the TP53 tumour suppressor gene are found in~ 50% of human cancers [,,,,–].
TP53 functions as a transcription factor that directly regulates the expression of~ 500 genes …
TP53 functions as a transcription factor that directly regulates the expression of~ 500 genes …
Cell death signaling
DR Green, F Llambi - Cold Spring Harbor perspectives …, 2015 - cshperspectives.cshlp.org
In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …
homeostasis and eliminates potentially harmful cells. There are three major types of …
BCL-2 protein family: attractive targets for cancer therapy
D Kaloni, ST Diepstraten, A Strasser, GL Kelly - Apoptosis, 2023 - Springer
Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …
suicide programme that is essential for development, tissue homeostasis and immunity. Too …
BH3-mimetic drugs: blazing the trail for new cancer medicines
Defects in apoptotic cell death can promote cancer and impair responses of malignant cells
to anti-cancer therapy. Pro-survival BCL-2 proteins prevent apoptosis by kee** the cell …
to anti-cancer therapy. Pro-survival BCL-2 proteins prevent apoptosis by kee** the cell …
Of the many cellular responses activated by TP53, which ones are critical for tumour suppression?
AF Thomas, GL Kelly, A Strasser - Cell Death & Differentiation, 2022 - nature.com
The tumour suppressor TP53 is a master regulator of several cellular processes that
collectively suppress tumorigenesis. The TP53 gene is mutated in~ 50% of human cancers …
collectively suppress tumorigenesis. The TP53 gene is mutated in~ 50% of human cancers …
The BCL2 family: key mediators of the apoptotic response to targeted anticancer therapeutics
The ability of cancer cells to suppress apoptosis is critical for carcinogenesis. The BCL2
family proteins comprise the sentinel network that regulates the mitochondrial or intrinsic …
family proteins comprise the sentinel network that regulates the mitochondrial or intrinsic …