Owing to renal reabsorption and the loss of uricase activity, uric acid (UA) is strictly
maintained at a higher physiological level in humans than in other mammals, which …

Uric acid, the end-product of purine metabolism in humans, is not only a cause of gout, but
also may play roles in develo** cardiovascular diseases such as hypertension, atrial …

This article is published as part of a supplement sponsored by Kidney Disease: Improving
Global Outcomes (KDIGO). The opinions or views expressed in this supplement are those of …

Background Studies have suggested that evening dosing with antihypertensive therapy
might have better outcomes than morning dosing. The Treatment in Morning versus Evening …

Objective To develop recommendations for cardiovascular risk (CVR) management in gout,
vasculitis, systemic sclerosis (SSc), myositis, mixed connective tissue disease (MCTD) …

Background Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous
studies have shown that allopurinol has positive effects on several cardiovascular …

Serum uric acid (SUA) is significantly elevated in obesity, gout, type 2 diabetes mellitus, and
the metabolic syndrome and appears to contribute to the renal, cardiovascular and …

Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors
for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological …

Uric acid (UA) is the final product of purine metabolism in the human body, and impaired
purine metabolism can increase the uric acid in serum, finally resulting in hyperuricemia …

Hyperuricemia with consequent monosodium urate crystal deposition leads to gout,
characterized by painful, incapacitating inflammatory arthritis flares that are also associated …