Introduction: Molecular dynamics (MD) simulations can provide not only plentiful dynamical
structural information on biomacromolecules but also a wealth of energetic information …

Aberrant protein folding known as protein misfolding is counted as one of the striking factors
of neurodegenerative diseases. The extensive range of pathologies caused by protein …

Advances in Protein Chemistry and Structural Biology, Volume 138 covers reviews of
methodology and research in all aspects of protein chemistry, including …

Prion diseases uniquely manifest in three distinct forms: inherited, sporadic, and infectious.
Wild-type prions are responsible for the sporadic and infectious versions, while mutant …

Abstract Purpose of Review Fatal familiar insomnia (FFI) is an autosomal dominant inherited
prion disease caused by D178N mutation in the prion protein gene (PRNP D178N) …

Single amino acid substitutions (SAPs) belong to a class of SNPs in the coding region,
which alter the protein function during the translation process. Storage of more information …

The fold of a protein determines its function and its misfolding can result in loss-of-function
defects. In addition, for certain proteins their misfolding can lead to gain-of-function toxicities …

Studies conducted over the past few decades have demonstrated that rabbits are immune to
prion diseases (also known as transmissible spongiform encephalopathies (TSEs)). Unlike …

It was reported that buffalo is a low susceptibility species resisting to transmissible
spongiform encephalopathies (TSEs)(same as rabbits, horses, and dogs). TSEs, also called …

Objective This study was planned to evaluate the genetic diversity in the admixed and Teli (a
Hindu caste) populations of Maharashtra, India using 20 autosomal Short Tandem Repeat …