Ischemic stroke, producing a high mortality and morbidity rate, is a common clinical disease.
Enhancing the prevention and control of ischemic stroke is particularly important. Baicalin …

There is increasing evidence that some neuronal death after brain ischaemia is mediated by
the action of cysteine-requiring aspartate-directed proteases (caspases), the proteases …

MicroRNA (miRNA) functions in the pathogenesis of major neurodegenerative diseases
such as Alzheimer's disease (AD) are only beginning to emerge. We have observed …

Neurons are exposed to high levels of DNA damage from both physiological and
pathological sources. Neurons are post-mitotic and their loss cannot be easily recovered …

Mitochondrial dysfunction causes poorly understood tissue-specific pathology stemming
from primary defects in respiration, coupled with altered reactive oxygen species (ROS) …

Apoptosis and necrosis represent two distinct types of cell death. Apoptosis possesses
unique morphologic and biochemical features which distinguish this mechanism of …

We demonstrate that the histone deacetylase (HDAC) inhibitor drug trichostatin A (TSA)
reduces spinal cord inflammation, demyelination, neuronal and axonal loss and ameliorates …

Currently, there is no effective treatment for neurodegenerative disorders such as
Alzheimer's disease and Parkinson's disease. Thus, a major focus of neuroscience research …

The mode of neuronal death caused by cerebral ischemia and reperfusion appears on the
continuum between the poles of catastrophic necrosis and apoptosis: ischemic neurons …

Neurogenesis, or the production of new neurons, is regulated by physiological and
pathological processes including aging, stress, and brain injury. Many mitogenic and trophic …