Colonization of the human nasopharynx by pneumococcus is extremely common and is both
the primary reservoir for transmission and a prerequisite for disease. Current vaccines …

Streptococcus pneumoniae is a major cause of pneumonia, meningitis, and septicaemia
worldwide. Pneumococcal antimicrobial resistance (AMR) has been highlighted by the WHO …

Many bacterial species are composed of multiple lineages distinguished by extensive
variation in gene content. These often cocirculate in the same habitat, but the evolutionary …

Streptococcus pneumoniae continues to cause significant disease burden. Whilst
pneumococcal conjugate vaccines (PCV) have substantially reduced this burden, serotype …

Chemical synthesis of conjugate vaccines, consisting of a polysaccharide linked to a protein,
can be technically challenging, and in vivo bacterial conjugations (bioconjugations) have …

Background Studies have demonstrated a reduction for otitis media (OM) following the
introduction of seven-valent pneumococcal conjugate vaccine (PCV7), but this has not been …

Background A general recommendation for adult pneumococcal vaccination with 23-valent
polysaccharide vaccine (PPV23) for adults 60 and older has been in place in Germany since …

A comprehensive understanding of the dynamics of Streptococcus pneumoniae colonization
in conjunction with respiratory virus infections is essential for enhancing our knowledge of …

Protection conferred by pneumococcal polysaccharide conjugate vaccines (PCVs) is
associated with PCV-induced antibodies against vaccine-covered serotypes that exhibit …

Background Invasive pneumococcal disease (IPD) and pneumococcal pneumonia are
common and carry a significant morbidity and mortality. Current strategies to prevent …