Malaria: the past and the present

J Talapko, I Škrlec, T Alebić, M Jukić, A Včev - Microorganisms, 2019 - mdpi.com
Malaria is a severe disease caused by parasites of the genus Plasmodium, which is
transmitted to humans by a bite of an infected female mosquito of the species Anopheles …

Artemisinins: pharmacological actions beyond anti-malarial

WE Ho, HY Peh, TK Chan, WSF Wong - Pharmacology & therapeutics, 2014 - Elsevier
Artemisinins are a family of sesquiterpene trioxane lactone anti-malarial agents originally
derived from Artemisia annua L. The anti-malarial action of artemisinins involves the …

Chemotherapy of leishmaniasis: present challenges

SRB Uliana, CT Trinconi, AC Coelho - Parasitology, 2018 - cambridge.org
Cutaneous and visceral leishmaniasis are amongst the most devastating infectious diseases
of our time, affecting millions of people worldwide. The treatment of these serious diseases …

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

W Wong, X Bai, A Brown, IS Fernandez, E Hanssen… - elife, 2014 - elifesciences.org
Malaria inflicts an enormous burden on global human health. The emergence of parasite
resistance to front-line drugs has prompted a renewed focus on the repositioning of clinically …

Discovery, mechanisms of action and combination therapy of artemisinin

L Cui, X Su - Expert review of anti-infective therapy, 2009 - Taylor & Francis
Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …

Opportunities and challenges in antiparasitic drug discovery

R Pink, A Hudson, MA Mouriès, M Bendig - Nature reviews Drug …, 2005 - nature.com
New antiparasitic drugs are urgently needed to treat and control diseases such as malaria,
leishmaniasis, slee** sickness and filariasis, which affect millions of people each year …

[HTML][HTML] Artemisinins: their growing importance in medicine

S Krishna, L Bustamante, RK Haynes… - Trends in pharmacological …, 2008 - cell.com
Artemisinins are derived from extracts of sweet wormwood (Artemisia annua) and are well
established for the treatment of malaria, including highly drug-resistant strains. Their efficacy …

Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance

R Bhat, AA Karim - Fitoterapia, 2010 - Elsevier
Eurycoma longifolia Jack is an herbal medicinal plant of South-East Asian origin, popularly
recognized as 'Tongkat Ali.'The plant parts have been traditionally used for its antimalarial …

A randomised, double blind, placebo-controlled pilot study of oral artesunate therapy for colorectal cancer

S Krishna, S Ganapathi, IC Ster, MEM Saeed… - …, 2015 - thelancet.com
Background Artesunate is an antimalarial agent with broad anti-cancer activity in in vitro and
animal experiments and case reports. Artesunate has not been studied in rigorous clinical …

Selective release of multiple DNA oligonucleotides from gold nanorods

A Wijaya, SB Schaffer, IG Pallares… - ACS nano, 2009 - ACS Publications
Combination therapy, or the use of multiple drugs, has been proven to be effective for
complex diseases, but the differences in chemical properties and pharmacokinetics can be …