Advances in the development of new tuberculosis drugs and treatment regimens
Despite the introduction 40 years ago of the inexpensive and effective four-drug (isoniazid,
rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to …
rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to …
The global tuberculosis epidemic and progress in care, prevention, and research: an overview in year 3 of the End TB era
Tuberculosis is the number one cause of death from infectious disease globally and drug-
resistant forms of the disease are a major risk to global health security. On the occasion of …
resistant forms of the disease are a major risk to global health security. On the occasion of …
Cyclobutanes in small‐molecule drug candidates
MR van der Kolk, MACH Janssen, FPJT Rutjes… - …, 2022 - Wiley Online Library
Cyclobutanes are increasingly used in medicinal chemistry in the search for relevant
biological properties. Important characteristics of the cyclobutane ring include its unique …
biological properties. Important characteristics of the cyclobutane ring include its unique …
Tuberculosis prevalence in China, 1990–2010; a longitudinal analysis of national survey data
L Wang, H Zhang, Y Ruan, DP Chin, Y **a, S Cheng… - The Lancet, 2014 - thelancet.com
Background China scaled up a tuberculosis control programme (based on the directly
observed treatment, short-course [DOTS] strategy) to cover half the population during the …
observed treatment, short-course [DOTS] strategy) to cover half the population during the …
The role of vaccines in preventing bacterial antimicrobial resistance
KU Jansen, C Knirsch, AS Anderson - Nature medicine, 2018 - nature.com
Antimicrobial resistance (AMR) and the associated morbidity and mortality due to bacterial
pathogens have been increasing globally to alarming levels. The World Health Organization …
pathogens have been increasing globally to alarming levels. The World Health Organization …
Tuberculous meningitis: more questions, still too few answers
GE Thwaites, R van Toorn, J Schoeman - The Lancet Neurology, 2013 - thelancet.com
Tuberculous meningitis is especially common in young children and people with untreated
HIV infection, and it kills or disables roughly half of everyone affected. Childhood disease …
HIV infection, and it kills or disables roughly half of everyone affected. Childhood disease …
Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled …
Summary Background The Xpert MTB/RIF test for tuberculosis is being rolled out in many
countries, but evidence is lacking regarding its implementation outside laboratories, ability to …
countries, but evidence is lacking regarding its implementation outside laboratories, ability to …
[BOOK][B] Systematic screening for active tuberculosis: principles and recommendations
World Health Organization - 2013 - books.google.com
There have been calls to revisit the experiences of TB screening campaigns that were
widely applied in Europe and North America in the mid-20th century, as well as more recent …
widely applied in Europe and North America in the mid-20th century, as well as more recent …
Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test
Rapid progress has been made in the development of new diagnostic assays for
tuberculosis in recent years. New technologies have been developed and assessed, and …
tuberculosis in recent years. New technologies have been developed and assessed, and …
Use of collateral sensitivity networks to design drug cycling protocols that avoid resistance development
New drug deployment strategies are imperative to address the problem of drug resistance,
which is limiting the management of infectious diseases and cancers. We evolved resistance …
which is limiting the management of infectious diseases and cancers. We evolved resistance …