Cancer-related diseases represent the second overall cause of death worldwide. Human
papilloma virus (HPV) is an infectious agent which is mainly sexually transmitted and may …

Between the 1960s and 1980s, most life scientists focused their attention on studies of
nucleic acids and the translation of the coded information. Protein degradation was a …

The ubiquitin-dependent proteolytic pathway plays a major role in selective protein
degradation. Ubiquitination of proteins requires the sequential action of the ubiquitin …

The tumor suppressor p53 is degraded by the ubiquitin-proteasome system. p53 was
polyubiquitinated in the presence of E1, UbcH5 as E2 and MDM2 oncoprotein. A ubiquitin …

As the tale of p53 unfolds, it becomes ever more intriguing. Although our understanding of
the critical and complex roles played by p53 is progressing rapidly, new findings continue to …

Mammalian cells contain two distinct proteolytic pathways that are involved in different
aspects of protein breakdown. Proteins that enter the cell from the extracellular milieu (such …

Angelman syndrome (AS), characterized by mental retardation, seizures, frequent smiling
and laughter, and abnormal gait, is one of the best examples of human disease in which …

Papillomaviruses are small nonenveloped viruses with 55-nm-diameter icosahedral capsids
that contain double-stranded DNA genomes of approximately 8,000 bp. They are widely …

E6-AP is a 100-kDa cellular protein that interacts with the E6 protein of the cancer-
associated human papillomavirus types 16 and 18. The E6/E6-AP complex binds to and …

UBIQUITINATION of proteins involves the concerted action of the El ubiquitin-activating
enzyme, E2 ubiquitin-conjugating enzymes and E3 ubiquitin–protein 1igases1–3. It has …