The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …
tuberculosis remains out of control in several parts of the world including Africa and Asia …
Clinical use of whole genome sequencing for Mycobacterium tuberculosis
Drug-resistant tuberculosis (TB) remains a major challenge to global health and to
healthcare in the UK. In 2014, a total of 6,520 cases of TB were recorded in England, of …
healthcare in the UK. In 2014, a total of 6,520 cases of TB were recorded in England, of …
CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis
S Li, NC Poulton, JS Chang, ZA Azadian… - Nature …, 2022 - nature.com
Mycobacterium tuberculosis (Mtb) infection is notoriously difficult to treat. Treatment efficacy
is limited by Mtb's intrinsic drug resistance, as well as its ability to evolve acquired resistance …
is limited by Mtb's intrinsic drug resistance, as well as its ability to evolve acquired resistance …
Precise phylogenetic analysis of microbial isolates and genomes from metagenomes using PhyloPhlAn 3.0
Microbial genomes are available at an ever-increasing pace, as cultivation and sequencing
become cheaper and obtaining metagenome-assembled genomes (MAGs) becomes more …
become cheaper and obtaining metagenome-assembled genomes (MAGs) becomes more …
The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis
Background Molecular diagnostics are considered the most promising route to achievement
of rapid, universal drug susceptibility testing for Mycobacterium tuberculosis complex …
of rapid, universal drug susceptibility testing for Mycobacterium tuberculosis complex …
Genome-based prediction of bacterial antibiotic resistance
Clinical microbiology has long relied on growing bacteria in culture to determine
antimicrobial susceptibility profiles, but the use of whole-genome sequencing for antibiotic …
antimicrobial susceptibility profiles, but the use of whole-genome sequencing for antibiotic …
Building a tuberculosis-free world: The Lancet Commission on tuberculosis
Executive summary Tuberculosis can be treated, prevented, and cured. Rapid, sustained
declines in tuberculosis deaths in many countries during the past 50 years provide …
declines in tuberculosis deaths in many countries during the past 50 years provide …
Prediction of susceptibility to first-line tuberculosis drugs by DNA sequencing
CRyPTIC Consortium and the 100,000 … - … England Journal of …, 2018 - Mass Medical Soc
Abstract Background The World Health Organization recommends drug-susceptibility testing
of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment …
of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment …
Stepwise pathogenic evolution of Mycobacterium abscessus
JM Bryant, KP Brown, S Burbaud, I Everall… - Science, 2021 - science.org
INTRODUCTION Nearly all mycobacterial species are free-living environmental
saprophytes. A few, such as Mycobacterium tuberculosis, have evolved to cause …
saprophytes. A few, such as Mycobacterium tuberculosis, have evolved to cause …
Advances in molecular diagnosis of tuberculosis
Molecular tests for tuberculosis (TB) have the potential to help reach the three million people
with TB who are undiagnosed or not reported each year and to improve the quality of care …
with TB who are undiagnosed or not reported each year and to improve the quality of care …