The cellular and physiological basis for lung repair and regeneration: past, present, and future
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …
Application of 3D bioprinting in the prevention and the therapy for human diseases
Rapid development of vaccines and therapeutics is necessary to tackle the emergence of
new pathogens and infectious diseases. To speed up the drug discovery process, the …
new pathogens and infectious diseases. To speed up the drug discovery process, the …
Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19
C Tindle, MK Fuller, A Fonseca, S Taheri… - Elife, 2021 - elifesciences.org
Background: SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage
in the lungs in the setting of an overzealous immune response whose origin remains …
in the lungs in the setting of an overzealous immune response whose origin remains …
Microfluidic organoids-on-a-chip: Quantum leap in cancer research
Simple Summary Organoids, also known as self-organized 3D organ-like clusters, represent
almost a physiological system for studying cells, stem cells, tissues, and diseases, especially …
almost a physiological system for studying cells, stem cells, tissues, and diseases, especially …
Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain
The emergence of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), the
etiological agent of the 2019 coronavirus disease (COVID-19), has erupted into a global …
etiological agent of the 2019 coronavirus disease (COVID-19), has erupted into a global …
Organoids: a novel modality in disease modeling
Limitations of monolayer culture conditions have motivated scientists to explore new models
that can recapitulate the architecture and function of human organs more accurately. Recent …
that can recapitulate the architecture and function of human organs more accurately. Recent …
A distal lung organoid model to study interstitial lung disease, viral infection and human lung development
Organoids have been an exciting advancement in stem cell research. Here we describe a
strategy for directed differentiation of human pluripotent stem cells into distal lung organoids …
strategy for directed differentiation of human pluripotent stem cells into distal lung organoids …
Organoid models for infectious disease
SE Blutt, MK Estes - Annual review of medicine, 2022 - annualreviews.org
Infectious diseases affect individual health and have widespread societal impacts. New ex
vivo models are critical to understand pathogenesis, host response, and features necessary …
vivo models are critical to understand pathogenesis, host response, and features necessary …
Organoid engineering with microfluidics and biomaterials for liver, lung disease, and cancer modeling
SK Kim, YH Kim, S Park, SW Cho - Acta biomaterialia, 2021 - Elsevier
As life expectancy improves and the number of people suffering from various diseases
increases, the need for develo** effective personalized disease models is rapidly rising …
increases, the need for develo** effective personalized disease models is rapidly rising …