Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer
The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk
transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed …
transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed …
[HTML][HTML] A comprehensive overview of RNA deconvolution methods and their application
Tumors are surrounded by a variety of tumor microenvironmental cells. Profiling individual
cells within the tumor tissues is crucial to characterize the tumor microenvironment and its …
cells within the tumor tissues is crucial to characterize the tumor microenvironment and its …
GATA6 expression distinguishes classical and basal-like subtypes in advanced pancreatic cancer
Purpose: To determine the impact of basal-like and classical subtypes in advanced
pancreatic ductal adenocarcinoma (PDAC) and to explore GATA6 expression as a surrogate …
pancreatic ductal adenocarcinoma (PDAC) and to explore GATA6 expression as a surrogate …
Organoid sensitivity correlates with therapeutic response in patients with pancreatic cancer
Purpose: Pancreatic ductal adenocarcinoma (PDAC) remains a significant health issue. For
most patients, there are no options for targeted therapy, and existing treatments are limited …
most patients, there are no options for targeted therapy, and existing treatments are limited …
S ub-C luster I dentification through S emi-S upervised O ptimization of R are-Cell S ilhouettes (SCISSORS) in single-cell RNA-sequencing
Motivation Single-cell RNA-sequencing (scRNA-seq) has enabled the molecular profiling of
thousands to millions of cells simultaneously in biologically heterogenous samples …
thousands to millions of cells simultaneously in biologically heterogenous samples …
Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer
Background A significant gap in pancreatic ductal adenocarcinoma (PDAC) patient's care is
the lack of molecular parameters characterizing tumours and allowing a personalized …
the lack of molecular parameters characterizing tumours and allowing a personalized …
Tumor phylogeography reveals block-shaped spatial heterogeneity and the mode of evolution in Hepatocellular Carcinoma
Solid tumors are complex ecosystems with heterogeneous 3D structures, but the spatial intra-
tumor heterogeneity (sITH) at the macroscopic (ie, whole tumor) level is under-explored …
tumor heterogeneity (sITH) at the macroscopic (ie, whole tumor) level is under-explored …
Establishment of a reference single-cell RNA sequencing dataset for human pancreatic adenocarcinoma
R Chijimatsu, S Kobayashi, Y Takeda, M Kitakaze… - IScience, 2022 - cell.com
Single-cell RNA sequencing (scRNAseq) has been used to assess the intra-tumor
heterogeneity and microenvironment of pancreatic ductal adenocarcinoma (PDAC) …
heterogeneity and microenvironment of pancreatic ductal adenocarcinoma (PDAC) …
Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion
Pancreatic ductal adenocarcinoma (PDAC) frequently presents with metastasis, but the
molecular programs in human PDAC cells that drive invasion are not well understood. Using …
molecular programs in human PDAC cells that drive invasion are not well understood. Using …
Mitochondrial genetic variations in leukemia: a comprehensive overview
A Zhang, W Liu, S Qiu - Blood Science, 2024 - journals.lww.com
Leukemias are a group of heterogeneous hematological malignancies driven by diverse
genetic variations, and the advent of genomic sequencing technologies facilitates the …
genetic variations, and the advent of genomic sequencing technologies facilitates the …