The lysosome as a command-and-control center for cellular metabolism
Lysosomes are membrane-bound organelles found in every eukaryotic cell. They are widely
known as terminal catabolic stations that rid cells of waste products and scavenge metabolic …
known as terminal catabolic stations that rid cells of waste products and scavenge metabolic …
Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers
Despite nearly two decades passing since the discovery of gene fusions involving TFE3 or
TFEB in sporadic renal cell carcinoma (RCC), the molecular mechanisms underlying the …
TFEB in sporadic renal cell carcinoma (RCC), the molecular mechanisms underlying the …
The International Society of Urological Pathology (ISUP) vancouver classification of renal neoplasia
The classification working group of the International Society of Urological Pathology
consensus conference on renal neoplasia was in charge of making recommendations …
consensus conference on renal neoplasia was in charge of making recommendations …
Integrated exome and RNA sequencing of TFE3-translocation renal cell carcinoma
G Sun, J Chen, J Liang, X Yin, M Zhang, J Yao… - Nature …, 2021 - nature.com
TFE3-translocation renal cell carcinoma (TFE3-tRCC) is a rare and heterogeneous subtype
of kidney cancer with no standard treatment for advanced disease. We describe …
of kidney cancer with no standard treatment for advanced disease. We describe …
MiT family translocation renal cell carcinoma
P Argani - Seminars in diagnostic pathology, 2015 - Elsevier
The MiT subfamily of transcription factors includes TFE3, TFEB, TFC, and MiTF. Gene
fusions involving two of these transcription factors have been identified in renal cell …
fusions involving two of these transcription factors have been identified in renal cell …
TFE3-fusion variant analysis defines specific clinicopathologic associations among Xp11 translocation cancers
Xp11 translocation cancers include Xp11 translocation renal cell carcinoma (RCC), Xp11
translocation perivascular epithelioid cell tumor (PEComa), and melanotic Xp11 …
translocation perivascular epithelioid cell tumor (PEComa), and melanotic Xp11 …
Proteogenomic characterization of MiT family translocation renal cell carcinoma
Y Qu, X Wu, A Anwaier, J Feng, W Xu, X Pei… - Nature …, 2022 - nature.com
Microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) is
a rare type of kidney cancer, which is not well characterized. Here we show the …
a rare type of kidney cancer, which is not well characterized. Here we show the …
Defining early-onset kidney cancer: implications for germline and somatic mutation testing and clinical management
Purpose Approximately 5% to 8% of renal cell carcinoma (RCC) is hereditary. No guidelines
exist for patient selection for RCC germline mutation testing. We evaluate how age of onset …
exist for patient selection for RCC germline mutation testing. We evaluate how age of onset …
[HTML][HTML] Current approaches for avoiding the limitations of circulating tumor cells detection methods—implications for diagnosis and treatment of patients with solid …
Eight million people die of cancer each year and 90% of deaths are caused by systemic
disease. Circulating tumor cells (CTCs) contribute to the formation of metastases and thus …
disease. Circulating tumor cells (CTCs) contribute to the formation of metastases and thus …
Translocation carcinomas of the kidney
P Argani - Genes, Chromosomes and Cancer, 2022 - Wiley Online Library
The MiT subfamily of transcription factors includes TFE3, TFEB, TFEC, and MITF. Gene
fusions involving two of these transcription factors have been well‐characterized in renal cell …
fusions involving two of these transcription factors have been well‐characterized in renal cell …