Be cool to be far: Exploiting hibernation for space exploration

M Cerri, T Hitrec, M Luppi, R Amici - Neuroscience & Biobehavioral …, 2021 - Elsevier
In mammals, torpor/hibernation is a state that is characterized by an active reduction in
metabolic rate followed by a progressive decrease in body temperature. Torpor was …

The central control of energy expenditure: exploiting torpor for medical applications

M Cerri - Annual review of physiology, 2017 - annualreviews.org
Autonomic thermoregulation is a recently acquired function, as it appears for the first time in
mammals and provides the brain with the ability to control energy expenditure. The …

A novel population of wake-promoting GABAergic neurons in the ventral lateral hypothalamus

A Venner, C Anaclet, RY Broadhurst, CB Saper… - Current Biology, 2016 - cell.com
The largest synaptic input to the sleep-promoting ventrolateral preoptic area (VLPO)[1]
arises from the lateral hypothalamus [2], a brain area associated with arousal [3–5] …

Lateral hypothalamic neurotensin neurons promote arousal and hyperthermia

F Naganuma, D Kroeger, SS Bandaru, G Absi… - PLoS …, 2019 - journals.plos.org
Sleep and wakefulness are greatly influenced by various physiological and psychological
factors, but the neuronal elements responsible for organizing sleep-wake behavior in …

Control of wakefulness by lateral hypothalamic glutamatergic neurons in male mice

R Wang, H Guo, S Jiang, Z Liu, W Qu… - Journal of …, 2021 - Wiley Online Library
The lateral hypothalamus (LH) plays a key role in the maintenance of cortical activation and
wakefulness. In the LH, the two main neuronal cell populations consist of excitatory …

Regulation of wakefulness by astrocytes in the lateral hypothalamus

P Cai, SN Huang, ZH Lin, Z Wang, RF Liu, WH **ao… - …, 2022 - Elsevier
The lateral hypothalamus (LH) is an important brain region mediating sleep–wake behavior.
Recent evidence has shown that astrocytes in central nervous system modulate the activity …

Activation of orexin-A (hypocretin-1) receptors in the Raphe Pallidus at different ambient temperatures in the rat: effects on thermoregulation, cardiovascular control …

T Hitrec, F Del Vecchio, L Alberti, M Luppi… - Frontiers in …, 2024 - frontiersin.org
The Raphe Pallidus (RPa) is a brainstem nucleus containing sympathetic premotor neurons
that control thermogenesis and modulate cardiovascular function. It receives inputs from …

Distinct lateral hypothalamic CaMKIIα neuronal populations regulate wakefulness and locomotor activity

JE Heiss, P Zhong, SM Lee… - Proceedings of the …, 2024 - National Acad Sciences
For nearly a century, evidence has accumulated indicating that the lateral hypothalamus
(LH) contains neurons essential to sustain wakefulness. While lesion or inactivation of LH …

[HTML][HTML] Loss of Snord116 impacts lateral hypothalamus, sleep, and food-related behaviors

M Pace, M Falappa, A Freschi, E Balzani, C Berteotti… - JCI insight, 2020 - ncbi.nlm.nih.gov
Imprinted genes are highly expressed in the hypothalamus; however, whether specific
imprinted genes affect hypothalamic neuromodulators and their functions is unknown. It has …

Is adenosine action common ground for NREM sleep, torpor, and other hypometabolic states?

A Silvani, M Cerri, G Zoccoli, SJ Swoap - Physiology, 2018 - journals.physiology.org
This review compares two states that lower energy expenditure: non-rapid eye movement
(NREM) sleep and torpor. Knowledge on mechanisms common to these states, and …