Self-driving laboratories for chemistry and materials science
Self-driving laboratories (SDLs) promise an accelerated application of the scientific method.
Through the automation of experimental workflows, along with autonomous experimental …
Through the automation of experimental workflows, along with autonomous experimental …
Chemistry of lipid nanoparticles for RNA delivery
Conspectus Lipid nanoparticles (LNPs) are a type of lipid vesicles that possess a
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
homogeneous lipid core. These vesicles are widely used in small-molecule drug and …
Microfluidic devices: a tool for nanoparticle synthesis and performance evaluation
The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment of
diseases for which conventional therapies present serious limitations. Additionally, NPs can …
diseases for which conventional therapies present serious limitations. Additionally, NPs can …
Correlating the structure and gene silencing activity of oligonucleotide-loaded lipid nanoparticles using small-angle X-ray scattering
With three FDA-approved products, lipid nanoparticles (LNPs) are under intensive
development for delivering wide-ranging nucleic acid therapeutics. A significant challenge …
development for delivering wide-ranging nucleic acid therapeutics. A significant challenge …
Lipid nanoparticles for siRNA delivery in cancer treatment
RNA-based therapies, and siRNAs in particular, have attractive therapeutic potential for
cancer treatment due to their ability to silence genes that are imperative for tumor …
cancer treatment due to their ability to silence genes that are imperative for tumor …
Design of experiments in the optimization of nanoparticle-based drug delivery systems
Abstract Design of experiment (DoE) is a powerful statistical technique used for variable
screening and optimization. It is based on the simultaneous variation of multiple factors with …
screening and optimization. It is based on the simultaneous variation of multiple factors with …
Self-driving laboratories: A paradigm shift in nanomedicine development
Nanomedicines have transformed promising therapeutic agents into clinically approved
medicines with optimal safety and efficacy profiles. This is exemplified by the mRNA …
medicines with optimal safety and efficacy profiles. This is exemplified by the mRNA …
Process robustness in lipid nanoparticle production: a comparison of microfluidic and turbulent jet mixing
The recent clinical and commercial success of lipid nanoparticles (LNPs) for nucleic acid
delivery has incentivized the development of new technologies to manufacture LNPs. As …
delivery has incentivized the development of new technologies to manufacture LNPs. As …
Comparative study of lipid nanoparticle-based mRNA vaccine bioprocess with machine learning and combinatorial artificial neural network-design of experiment …
To develop a combinatorial artificial-neural-network design-of-experiment (ANN-DOE)
model, the effect of ionizable lipid, an ionizable lipid-to-cholesterol ratio, N/P ratio, flow rate …
model, the effect of ionizable lipid, an ionizable lipid-to-cholesterol ratio, N/P ratio, flow rate …
Microfluidics for nano-drug delivery systems: from fundamentals to industrialization
H Zhang, J Yang, R Sun, S Han, Z Yang… - Acta Pharmaceutica Sinica …, 2023 - Elsevier
In recent years, owing to the miniaturization of the fluidic environment, microfluidic
technology offers unique opportunities for the implementation of nano drug delivery systems …
technology offers unique opportunities for the implementation of nano drug delivery systems …